24108-40-5

Usage

Uses

Used in Pharmaceutical Industry:
3-Phenyl-1,2,4-triazine is used as a key intermediate in the synthesis of various pharmaceuticals due to its unique molecular structure and potential biological activities. It aids in the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Phenyl-1,2,4-triazine serves as a crucial component in the creation of effective pesticides and other crop protection agents, enhancing agricultural productivity and crop safety.
Used in Dye and Pigment Production:
3-Phenyl-1,2,4-triazine is utilized as a vital constituent in the manufacturing of dyes and pigments, contributing to the production of vibrant colors and stable compounds for various applications, including textiles, plastics, and printing inks.
Used in Antiviral, Antibacterial, and Antitumor Applications:
3-Phenyl-1,2,4-triazine is studied for its potential use as an antiviral, antibacterial, and antitumor agent, highlighting its broad-spectrum activity against various pathogens and its potential in cancer treatment. Its biological properties make it a promising candidate for further research and development in the medical field.

Upstream product

• 960-16-7 tributylphenylstannane 
• 28735-21-9 3-methylthio-1,2,4-triazine 
• 38111-44-3 phenylzinc(II) bromide 
• 98-80-6 phenylboronic acid 

Downstream Products

• 94243-20-6 1-(3-phenyl-1,2,4-triazin-5-yl)ethanone oxime 
• 94243-17-1 oxime of 5-formyl-3-phenyl-1,2,4-triazine 
• 87505-19-9 3-phenyl-5-(phenylsulfonyl)methyl-1,2,4-triazine 
• 114468-11-0 3-phenyl-5-<1-(phenylsulfonyl)ethyl>-1,2,4-triazine 
• 99512-67-1 5-amino-3-phenyl-1,2,4-triazine 
• 188356-59-4 1-(3-Phenyl-[1,2,4]triazin-5-yl)-propan-1-one oxime 
• 310888-36-9 C₁₈H₁₇N₅ 
• 496935-66-1 C₁₈H₁₇N₅ 

Relevant academic research and scientific papers

Reinvestigation of the reaction of 3-substituted 1,2,4-triazines with nitronate anions: unexpected behavior of 3-(2-ethoxyphenyl)-1,2,4-triazine in the reaction with anions of nitroalkanes

[Figure not available: see fulltext.] 3-Substituted 1,2,4-triazines easily react with nitronate anions to replace hydrogen atom in the position C-5 according to nucleophilic substitution mechanism and form appropriate oximes of 5-formyl- or 5-acyl-1,2,4-t

1,2,4-Triazines Are Versatile Bioorthogonal Reagents

A new class of bioorthogonal reagents, 1,2,4-triazines, is described. These scaffolds are stable in biological media and capable of robust reactivity with trans-cyclooctene (TCO). The enhanced stability of the triazine scaffold enabled its direct use in recombinant protein production. The triazine-TCO reaction can also be used in tandem with other bioorthogonal cycloaddition reactions. These features fill current voids in the bioorthogonal toolkit.

A general approach to selective functionalization of 1,2,4-triazines using organometallics in palladium-catalyzed cross-coupling and addition reactions

A selective way to obtain disubstituted 1,2,4-triazines in good yields by combining addition reactions and palladium-catalyzed cross-coupling reactions of organometallics with 3-methylsulfanyl-1,2,4-triazine is described.

Copper(I)-promoted palladium-catalyzed cross-coupling of unsaturated tri-n-butylstannane with heteroaromatic thioether

(Matrix presented) Palladium-catalyzed cross-coupling of vinyl- and arylstannanes with π-electron-deficient heteroaromatics was performed in good yields. This Stille-type reaction was carried out with a methylthioether function as an electrophile in the presence of a copper(I) bromide-dimethyl sulfide complex.