24108-46-1Relevant academic research and scientific papers
1,2,4-Triazines Are Versatile Bioorthogonal Reagents
Kamber, David N.,Liang, Yong,Blizzard, Robert J.,Liu, Fang,Mehl, Ryan A.,Houk,Prescher, Jennifer A.
, p. 8388 - 8391 (2015)
A new class of bioorthogonal reagents, 1,2,4-triazines, is described. These scaffolds are stable in biological media and capable of robust reactivity with trans-cyclooctene (TCO). The enhanced stability of the triazine scaffold enabled its direct use in recombinant protein production. The triazine-TCO reaction can also be used in tandem with other bioorthogonal cycloaddition reactions. These features fill current voids in the bioorthogonal toolkit.
