24112-69-4Relevant academic research and scientific papers
Formation of Lactones via a Radical Ring Closure Mechanism
Beckwith, Athelstan L. J.,Pigou, Paul E.
, p. 85 - 86 (1986)
Suitable alkenoyloxymethyl iodides or selenides are converted into lactones upon treatment with tributyl-stannane or -germane; the reaction involves highly regioselective and stereoselective ring closure of alkenoyloxymethyl radicals (1).
A new strategy for the synthesis of himbacine
Casey, Mike,McCarthy, Robert
, p. 801 - 804 (2011/06/11)
A new strategy for the assembly of himbacine and analogues, which display potent biological activity, is described. A four-step route to a key intermediate has been developed, in which the key step is a highly diastereoselective Michael-Dieckmann domino reaction. Use of an enantioenriched Michael acceptor, readily obtained by an asymmetric dihydroxylation reaction, allowed kinetic resolution of the Michael donor, which was itself prepared by a domino reaction. Georg Thieme Verlag Stuttgart.
