76879-70-4Relevant academic research and scientific papers
Bis Heteroannulation. 2. Oxazole Alcohols from the Interaction of Lithiomethyl Isocyanide with Lactones. A Novel Synthesis of Evodone
Jacobi, Peter A.,Walker, Donald G.,Odeh, Imad M. A.
, p. 2065 - 2069 (2007/10/02)
Oxazole alcohols may be readily obtained through the interaction of lithiomethyl isocyanide with lactones.Acetylenic oxazoles of proper design have been shown to undergo a facile intramolecular Diels-Alder reaction, leading directly to fused-ring furan derivatives of the type found in the furanosesquiterpenes ("bis heteroannulation").A novel synthesis of evodone is presented.
