241125-54-2Relevant academic research and scientific papers
The sulfonimidamide as a novel transition state analog for aspartic acid and metallo proteases
Cathers, Brian E.,Schloss, John V.
, p. 1527 - 1532 (2007/10/03)
We have developed a novel strategy for the preparation of tetrahedral transition state analogs for aspartic acid and metallo-proteases based upon the sulfonimidamide functional group. Our best α-des-amino dipeptide analog binds at least 100-fold tighter than the corresponding ground state structure (i.e., amide). A previously unpublished five-membered cyclic sulfonimidamide was also synthesized.
