241125-56-4Relevant academic research and scientific papers
The sulfonimidamide as a novel transition state analog for aspartic acid and metallo proteases
Cathers, Brian E.,Schloss, John V.
, p. 1527 - 1532 (2007/10/03)
We have developed a novel strategy for the preparation of tetrahedral transition state analogs for aspartic acid and metallo-proteases based upon the sulfonimidamide functional group. Our best α-des-amino dipeptide analog binds at least 100-fold tighter than the corresponding ground state structure (i.e., amide). A previously unpublished five-membered cyclic sulfonimidamide was also synthesized.
Some Studies on Peptide Analogues Involving the Sulphinamide Group
Merricks, David,Sammes, Peter G.,Walker, Edward R. H.,Henrick, Kim,McPartlin, Mary M.
, p. 2169 - 2176 (2007/10/02)
The title compounds are of interest as possible transition state inhibitors of peptidases.A route to N-(alkylsulphinyl)amino acids is described.A method for generating α-benzamidosulphinamides is reported; a general route to such systems failed owing to t
