24115-80-8Relevant academic research and scientific papers
Palladium-catalyzed one-pot synthesis of highly substituted furans by a three-component annulation reaction
Duan, Xin-Hua,Liu, Xue-Yuan,Guo, Li-Na,Liao, Meng-Chun,Liu, Wei-Min,Liang, Yong-Min
, p. 6980 - 6983 (2005)
A new three-component cyclization-coupling reaction catalyzed by palladium was developed, producing polysubstituted furans in good yields from readily available substrates. The reaction conditions and the scope of the process were examined, and a possible mechanism is proposed.
Palladium-Catalyzed Oxidative Cycloisomerization of 2-Cinnamyl-1,3-Dicarbonyls: Synthesis of Functionalized 2-Benzyl Furans
Nallagonda, Rajender,Reddy, Reddy Rajasekhar,Ghorai, Prasanta
supporting information, p. 14732 - 14736 (2015/10/19)
A new palladium-catalyzed intramolecular oxidative cycloisomerization of readily available starting materials, 2-cinnamyl-1,3-dicarbonyls, has been demonstrated for the creation of structurally diverse 2-benzyl furans. The cycloisomerization occurs by a regioselective 5-exo-trig pathway. The reaction shows a broad substrate scope with good to excellent yields. Furthermore, a one-pot procedure has been executed by using readily available cinnamyl alcohols and 1,3-diketones. Cinnamyl verit: Palladium-catalyzed intramolecular oxidative cycloisomerization of readily available 2-cinnamyl-1,3-dicarbonyls affords structurally diverse 2-benzyl furans. The cycloisomerization occurs by a regioselective 5-exo-trig pathway, with a broad substrate scope in good to excellent yields. Furthermore, a one-pot procedure is executed by using readily available cinnamyl alcohols and 1,3-diketones
2,3-dihalo-1-propenes as building blocks in Cu(I)-catalyzed domino reactions: Efficient and selective synthesis of furans
Schmidt, Dietmar,Malakar, Chandi C.,Beifuss, Uwe
, p. 4862 - 4865 (2015/04/27)
The Cu(I)-catalyzed reaction of 2,3-dibromo-1-propenes with β-ketoesters and 1,3-diketones, respectively, in DMF at 120 °C using Cs2CO3 as a base and hydroquinone as an additive exclusively delivers 2,3,5-trisubstituted furans and related compounds with yields up to 96%. The highly regioselective domino process is based on an intermolecular C-allylation followed by an intramolecular Ullmann type O-vinylation and a double bond isomerization.
