241161-69-3

Basic information

• Product Name: 4-[(6-oxo-6,7-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-hydrazonomethyl]-benzoic acid
• Synonyms: 4-[(6-oxo-6,7-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-hydrazonomethyl]-benzoic acid
• CAS NO: 241161-69-3
• Molecular Weight: 298.261
• Mol File: 241161-69-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[(6-oxo-6,7-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-hydrazonomethyl]-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(6-oxo-6,7-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-hydrazonomethyl]-benzoic acid(241161-69-3)
• EPA Substance Registry System: 4-[(6-oxo-6,7-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-hydrazonomethyl]-benzoic acid(241161-69-3)

Safety Data

• Hazardous Substances Data: 241161-69-3(Hazardous Substances Data)

Upstream product

• 246855-07-2 6-Chloro-4-hydrazino-1H-pyrazolo[3,4-d]pyrimidine 
• 246855-09-4 N-benzylidene-N'-(6-chloro-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-hydrazine 
• 50270-27-4 2,4,6-trichloropyrimidine-5-carbaldehyde 
• 5334-33-8 4,5-Dihydro-4-thioxo-1H-pyrazolo[3,4-d]pyrimidin-6(7H)-one 
• 2465-59-0 oxypurinol 

Relevant articles and documents

Novel xanthine oxidase inhibitor studies. Part 3. Convenient and general syntheses of 3-substituted 7H-pyrazolo[4,3-e]-1,2,4-triazolo[4,3-c]pyrimidin-5(6H)-ones as a new class of potential xanthine oxidase inhibitors

Convenient and general syntheses of 3-substituted 7H-pyrazolo[4,3-e]-1,2,4-triazolo[4,3-c]pyrimidin-5(6H)-ones (12), a new class of potent xanthine oxidase inhibitors, involving the oxidative cyclisation of 6-substituted 4-alkylidenehydrazino- or 4-arylmethylidenehydrazino-1H-pyrazolo[3,4-d]pyrimidines (3 and 11) with 70% nitric acid as the key step, are reported. The hydrazones 3 and 11 were obtained by a versatile synthetic route via the key intermediates, 6-chloro-4-hydrazino-1H-pyrazolo[3,4-d]pyrimidine 2 or oxypurinol 4, starting from 2,4,6-trichloropyrimidine-5-carbaldehyde 1. Their inhibitory activities against bovine milk xanthine oxidase in vitro are also described; i.e. the pyrazolotriazolopyrimidines 12 were several hundred times more potent than allopurinol.