5334-33-8

Upstream product

• 2465-59-0 oxypurinol 
• 463-58-1 carbon oxide sulfide 
• 16617-46-2 3-amino-4-cyano-2H-pyrazole 
• 110-86-1 pyridine 
• 50270-27-4 2,4,6-trichloropyrimidine-5-carbaldehyde 
• 246855-07-2 6-Chloro-4-hydrazino-1H-pyrazolo[3,4-d]pyrimidine 
• 246855-09-4 N-benzylidene-N'-(6-chloro-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-hydrazine 

Downstream Products

• 246855-16-3 5-chloro-3-phenyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine 
• 246855-18-5 5-chloro-3-(4-chloro-phenyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine 
• 246855-17-4 5-chloro-3-(4-fluoro-phenyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine 
• 246855-19-6 5-chloro-3-p-tolyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine 
• 246855-20-9 5-chloro-3-(4-methoxy-phenyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine 
• 246855-21-0 5-chloro-3-(4-nitro-phenyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine 
• 23771-52-0 4-amino-1,7-dihydro-pyrazolo[3,4-d]pyrimidine-6-thione 
• 241161-69-3 4-[(6-oxo-6,7-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-hydrazonomethyl]-benzoic acid 
• 261717-75-3 4-{N'-[1-(4-Hydroxy-phenyl)-meth-(E)-ylidene]-hydrazino}-1,7-dihydro-pyrazolo[3,4-d]pyrimidin-6-one 
• 261717-74-2 4-{N'-[1-(4-Bromo-phenyl)-meth-(E)-ylidene]-hydrazino}-1,7-dihydro-pyrazolo[3,4-d]pyrimidin-6-one 
• 261717-73-1 4-{N'-[1-(3-Chloro-phenyl)-meth-(E)-ylidene]-hydrazino}-1,7-dihydro-pyrazolo[3,4-d]pyrimidin-6-one 
• 261717-72-0 4-{N'-[1-(2-Chloro-phenyl)-meth-(E)-ylidene]-hydrazino}-1,7-dihydro-pyrazolo[3,4-d]pyrimidin-6-one 

Relevant academic research and scientific papers

Novel xanthine oxidase inhibitor studies. Part 3. Convenient and general syntheses of 3-substituted 7H-pyrazolo[4,3-e]-1,2,4-triazolo[4,3-c]pyrimidin-5(6H)-ones as a new class of potential xanthine oxidase inhibitors

Convenient and general syntheses of 3-substituted 7H-pyrazolo[4,3-e]-1,2,4-triazolo[4,3-c]pyrimidin-5(6H)-ones (12), a new class of potent xanthine oxidase inhibitors, involving the oxidative cyclisation of 6-substituted 4-alkylidenehydrazino- or 4-arylmethylidenehydrazino-1H-pyrazolo[3,4-d]pyrimidines (3 and 11) with 70% nitric acid as the key step, are reported. The hydrazones 3 and 11 were obtained by a versatile synthetic route via the key intermediates, 6-chloro-4-hydrazino-1H-pyrazolo[3,4-d]pyrimidine 2 or oxypurinol 4, starting from 2,4,6-trichloropyrimidine-5-carbaldehyde 1. Their inhibitory activities against bovine milk xanthine oxidase in vitro are also described; i.e. the pyrazolotriazolopyrimidines 12 were several hundred times more potent than allopurinol.

Facile and general syntheses of 3- and/or 5-substituted 7H-pyrazolo[4,3-e]-1,2,4-triazolo[4,3-c]pyrimidines as a new class of potential xanthine oxidase inhibitors

Convenient syntheses of 3- and/or 5-substituted 7H-pyrazolo[4,3-e]-1,2,4-triazolo[4,3-c]pyrimidines as a new class of potent xanthine oxidase inhibitors, involving the oxidative cyclisation of 4-alkylidenehydrazino- or 4-arylmethylidenehydrazino-1H-pyrazolo[3,4-d]pyrimidines with 70% nitric acid as the key step, are described.

A General Route for the Facile Synthesis of 4-Thioxopyrimidin-2-one Derivatives via the Annulation of Cyclic o-Aminonitriles Using Carbonyl Sulfide

A facile synthesis of 4,5-diamino-9-(β-D-ribofuranosyl)pyrrolodipyrimidin-7-one (6) from an appropriately substituted pyrrolopyrimidine has been accomplished.A key reaction in this synthesis involves the ring closure of a cyclic o-aminonitrile precursor by using carbonyl sulfide to obtain the versatile 4-thioxopyrimidin-2-one intermediate 3.A study involving the generality of this reagent for the annulation of cyclic o-aminonitriles under different reaction conditions is also discussed.