24125-33-5

Upstream product

• 3401-36-3 (N-benzyloxycarbonyl)-L-alanine N-hydroxysuccinimide ester 
• 127-06-0 acetone oxime 
• 1142-20-7 N-Cbz-Ala 

Relevant academic research and scientific papers

Pilot-Scale Lipase-Catalyzed Regioselective Acylation of Ribavirin in Anhydrous Media in the Synthesis of a Novel Prodrug Intermediate

The ester 4 was synthesized via Candida antarctica lipase-catalyzed acylation of ribavirin (3) with the oxime ester of L-Cbz-Ala (2) in anhydrous THF. The reaction was highly regioselective, resulting in the exclusive acylation of the 5′-hydroxyl. The pro

Selective aminoacylation of nucleosides through an enzymatic reaction with oxime aminoacyl esters

N-protected aminoacyl acetoxime esters are useful agents for enzymatic aminoacylation of 2'-deoxy- and ribo-nucleosides. In both cases, 5'-O- derivatives can be prepared if the lipase used is SP 435 (from Candida antarctica) whereas 3'-O-isomers from 2'-deoxynucleosides are obtained with Pseudomonas cepacia.