24128-88-9

Upstream product

• 125231-39-2 3-phenyl-1-[2,3,5,6-tetrafluoro-4-(piperidin-1-yl)phenyl]prop-2-en-1-one 
• 50-01-1 guanidine hydrochloride 
• 125231-44-9 1-phenyl-3-[2,3,5,6-tetrafluoro-4-(piperidin-1-yl)phenyl]prop-2-en-1-one 
• 110-89-4 piperidine 
• 24692-24-8 triethylgermylpentafluorobenzene 
• 15368-91-9 4-bromo-2,3,5,6-tetrafluoro-1-piperidinobenzene 
• 1206-46-8 trimethyl(pentafluorophenyl)silane 

Relevant academic research and scientific papers

Reaction of polyfluoroaromatic compounds with electrophilic agents in the presence of tris(dialkylamino)phosphines: 7. * Replacement of a halogen by hydrogen in halogenopolyfluoroaromatic compounds

A method was developed for the replacement of chlorine, bromine, and iodine in halopolyfluoroaromatic compounds by hydrogen under the action of P(NEt2)3 and a proton donor.

Reaction of polyfluorinated chalcones with guanidine

Reactions of polyfluorinated chalcones with guanidine in the presence of bases are accompanied by elimination of the polyfluorophenyl group. 3-(Pentafluorophenyl)-1-phenylprop-2-en-1-one and its derivatives reacted with guanidine under basic conditions to give 4-phenylpyrimidin-2-amine, polyfluorobenzenes, and Michael adducts, 3-(2-amino-4-phenylpyrimidin-5-yl)-3-(4-R-2,3,5,6-tetrafluorophenyl)-1-phenylpropan-1-ones. 1-(Pentafluorophenyl)-3-phenylprop-2-en-1-one and 1,3-bis(pentafluorophenyl)prop-2-en-1-one were converted into cinnamic acid derivatives whose reaction with guanidine afforded 2-amino-6-aryl-5,6-dihydropyrimidin-4(1H)-ones.