241465-87-2

Upstream product

• 915-35-5 hecogenin acetate 
• 241465-82-7 Dichloro-acetic acid (R)-4-((2S,4aS,4bS,6aS,6bR,9aS,10aS,10bR,12aS)-2-acetoxy-4a,6a,7-trimethyl-6-oxo-2,3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12,12a-hexadecahydro-1H-9-oxa-pentaleno[2,1-a]phenanthren-8-yl)-2-methyl-butyl ester 
• 125613-63-0 Acetic acid (2S,4aS,4bS,6aS,6bR,9aS,10aS,10bR,12aS)-8-((R)-4-hydroxy-3-methyl-butyl)-4a,6a,7-trimethyl-6-oxo-2,3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12,12a-hexadecahydro-1H-9-oxa-pentaleno[2,1-a]phenanthren-2-yl ester 

Relevant academic research and scientific papers

Consequences of acid catalysis in concurrent ring opening and halogenation of spiroketals

(formula presented) Lewis and/or Bronsted acid additives permit ring opening and halogenation of spiroketals at substantially reduced temperatures to produce ω-iodo enol ethers in improved yield and purity, which can undergo further reaction in the presen

Concurrent ring opening and halogenation of spiroketals

Ring opening of various spiroketals with triphenylphosphine dihalides under neutral conditions produced ω-halo-enolethers in good to excellent yield. The method transformed even the very stable spiroketal of hecogenin acetate at temperatures below any previously reported for such isomerative opening.