915-35-5 Usage
Description
Hecogenin acetate is a steroid sapogenin and an acetylated form of hecogenin that has anthelmintic and antinociceptive properties. It reduces the percentage of mobile larvae in goat fecal cultures containing Haemonchus, Oesophagostomum, and Trichostrongylus nematodes (EC50 = 0.49 mg/ml). Hecogenin acetate (5, 10, or 20 mg/kg, i.p.) inhibits development of mechanical hyperalgesia induced by carrageenan, TNF-α, dopamine , and prostaglandin E2 (PGE2; ) in mice. It also increases latency to tail withdrawal in the tail flick test and has no effect on motor performance in the rotarod test in mice when administered at a dose of 40 mg/kg.
Uses
Hecogenin Acetate, is a derivative of Hecogenin (H129945), which is a sapogenin present in the leaves of species from the Agave genus, possessing wide spectrum of pharmacology activities, such as having antinociceptive properties.
Purification Methods
Crystallise the acetate from MeOH. [Beilstein 19 IV 2583.]
Check Digit Verification of cas no
The CAS Registry Mumber 915-35-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,1 and 5 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 915-35:
(5*9)+(4*1)+(3*5)+(2*3)+(1*5)=75
75 % 10 = 5
So 915-35-5 is a valid CAS Registry Number.
InChI:InChI=1/C29H44O5/c1-16-8-11-29(32-15-16)17(2)26-24(34-29)13-23-21-7-6-19-12-20(33-18(3)30)9-10-27(19,4)22(21)14-25(31)28(23,26)5/h16-17,19-24,26H,6-15H2,1-5H3/t16?,17-,19-,20?,21?,22?,23?,24?,26?,27?,28?,29?/m0/s1
915-35-5Relevant articles and documents
-
Marker et al.
, (1947)
-
Synthesis of betamethasone from the waste of Thai Agave sisalana
Kongkathip, Ngampong,Kongkathip, Boonsong,Noimai, Naratitt
, p. 865 - 874 (2007/10/03)
Synthesis of betamethasone from waste of Thai A. sisalana is described. Copyright Taylor & Francis Group, LLC.
TRANSFORMATIONS OF SOLASODINE AND DERIVATIVES OF HECOGENIN BY CUNNINGHAMELLA ELEGANS
Patel, Asmita V.,Blunden, Gerald,Crabb, Trevor A.
, p. 125 - 134 (2007/10/02)
Incubation of (25R)-5α-spirostane-3β,12β-diol (rickogenin) with the fungus Cunninghamella elegans led to the formation of (25R)-7β,12β-dihydroxy-5α-spirostan-3-one, (25R)-5α-spirostan-3β,7β,12β-triol and (25R)-5α-spirostan-3β,7α,12α-triol.Incubation of (25R)-5α-spirostan-3,12-dione (hecogenone) with the same fungus gave rise to (25R)-5α-spirostan-3,7,12-trione.When the (22R,25R)-spirosolane, solasod-5-en-3β-ol (solasodine) was incubated with C. elegans, solasod-5-ene-3β,7β-diol, solasod-5-ene-3β,7α-diol and 3β-hydroxysolasod-5-en-7-one were produced.In contrast, incubation of solasodine with Penicillium patulum gave solasod-4-en-3-one and the 6-methylsalicylic acid salt of solasodine.