241472-64-0

Upstream product

• 2393-23-9 4-methoxy-benzylamine 
• 241472-57-1 bis[2-(p-toluenesulfonyloxy)ethyl]diphenylsilane 
• 82587-23-3 Bis-(2-bromethyl)-diphenylsilan 
• 241472-56-0 2,2'-(diphenylsilylene)bis(ethanol) 
• 17937-68-7 diphenyl-divinyl-silane 
• 80-10-4 diphenylsilyl dichloride 

Downstream Products

• 802982-54-3 2-methylpropionyl N-(4,4-diphenyl-4-silapiperidide) 

Relevant academic research and scientific papers

The extraordinary reactions of phenyldimethylsilyllithium with N,N-disubstituted amides

The reactions of the silyllithium reagent with tertiary amides was discussed. The enediamines were easily isomerized from cis to trans, easily oxidized to dienediamines and were hydrolyzed to α-aminoketones. If the two equivalents of the silyllithium reagent were used, the product was an α-silylamine. The results show that each member of the homologous series of amides gives rise to a substantially different product.

Diphenylsilyldiethylene- (DPSide-) group: A new primary amine protection

Diphenylsilydiethylene- (DPSide-) group has been developed as a new primary amine protecting group. The new protecting group exhibits novel orthogonality against other commonly used amine-protecting groups and excellent chemoselectivity for unbranched α-amino acid esters. Removal of this protecting group was effected under mild fluoride-based cleavage conditions.