241489-18-9

Upstream product

• 552-16-9 ortho-nitrobenzoic acid 
• 610-14-0 2-nitrobenzyl chloride 
• 241489-16-7 (S)-5-(Bis-ethylsulfanyl-methyl)-1-(2-nitro-benzoyl)-pyrrolidin-3-one 
• 214143-92-7 4-hydroxy-1-(2-nitrobenzoyl)pyrrolidine-2-carboxylic acid methyl ester 
• 315188-74-0 (2S)-N-(2-nitrobenzoyl)-(4R)-hydroxypyrrolidine-2-carboxylic acid 
• 241489-15-6 [(2S,4R)-2-(Bis-ethylsulfanyl-methyl)-4-hydroxy-pyrrolidin-1-yl]-(2-nitro-phenyl)-methanone 
• 315188-75-1 (2S,4R)-4-Hydroxy-1-(2-nitro-benzoyl)-pyrrolidine-2-carbaldehyde 
• 241489-17-8 [(S)-5-(Bis-ethylsulfanyl-methyl)-1-(2-nitro-benzoyl)-pyrrolidin-(3E)-ylidene]-acetic acid methyl ester 

Downstream Products

• 241489-21-4 2-[(S)-5-(Bis-ethylsulfanyl-methyl)-1-(2-nitro-benzoyl)-pyrrolidin-(3E)-ylidene]-N-(5-{2-[(S)-5-(bis-ethylsulfanyl-methyl)-1-(2-nitro-benzoyl)-pyrrolidin-(3E)-ylidene]-acetylamino}-pentyl)-acetamide 
• 474524-47-5 methyl (E)-3-[2-[(5S)-5-[bis(ethylthio)methyl]-1-(2-nitrobenzoyl)-tetrahydro-1H-3-pyrrolyliden]-acetamido]propionate 
• 474524-48-6 (E)-3-[2-[(5S)-5-[bis(ethylthio)methyl]-1-(2-nitrobenzoyl)-tetrahydro-1H-3-pyrrolyliden]-acetamido]propionic acid 
• 474524-49-7 4-(3-{2-[5-(bis-ethylsulfanyl-methyl)-1-(2-nitro-benzoyl)-pyrrolidin-3-ylidene]-acetylamino}-propionylamino)-1-methyl-1H-pyrrole-2-carboxylic acid (3-dimethylamino-propyl)-amide 
• 474524-50-0 C₃₈H₅₁N₉O₇S₂ 
• 474524-51-1 C₄₄H₅₇N₁₁O₈S₂ 
• 241489-20-3 2-[(S)-5-(Bis-ethylsulfanyl-methyl)-1-(2-nitro-benzoyl)-pyrrolidin-(3E)-ylidene]-N-(4-{2-[(S)-5-(bis-ethylsulfanyl-methyl)-1-(2-nitro-benzoyl)-pyrrolidin-(3E)-ylidene]-acetylamino}-butyl)-acetamide 
• 241489-19-0 2-[(S)-5-(Bis-ethylsulfanyl-methyl)-1-(2-nitro-benzoyl)-pyrrolidin-(3E)-ylidene]-N-(3-{2-[(S)-5-(bis-ethylsulfanyl-methyl)-1-(2-nitro-benzoyl)-pyrrolidin-(3E)-ylidene]-acetylamino}-propyl)-acetamide 

Relevant academic research and scientific papers

Design and synthesis of novel DNA interstrand cross-linking agents: C2-linked pyrrolo[2,1-c][1,4]benzodiazepine polyamide conjugates

The design and synthesis of C2- linked novel pyrrolo[2,1-c][1,4]benzodiazepine (PBD)-polyamide conjugates (1a - c) as DNA minor groove binding agents are described.

Design and efficient synthesis of novel DNA interstrand cross-linking agents: C2-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers

The design and facile synthesis of C2-linked pyrrolo[2,1-c][1,4]benzodiazepines (1a-c) are described. The compounds are prepared with varying degrees of linker length in order to probe the structural requirements for optimal DNA interstrand cross-linking.