24149-57-3Relevant academic research and scientific papers
1,2-Naphthoquinone-based Derivatives and and Methods for Preparing them
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Paragraph 0450; 0451; 0455-0457, (2016/11/24)
The present invention relates to a compound represented by chemical formula (1), a pharmaceutically acceptable salt, a hydrate, a solvate, a prodrug, a tautomer, an enantiomer, or a pharmaceutically acceptable diastereomer thereof, a preparing method thereof, and a medical composition having a treating or preventing effect of metabolic diseases containing the same. Here, R_1 to R_3, and X_1 to X_6 are the same as defined in a first claim.COPYRIGHT KIPO 2015
Synthesis and biological evaluation of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives
Shanab, Karem,Schirmer, Eva,Knafl, Heike,Wulz, Eva,Holzer, Wolfgang,Spreitzer, Helmut,Schmidt, Peter,Aicher, Babette,Mueller, Gilbert,Guenther, Eckhard
scheme or table, p. 3950 - 3952 (2010/09/03)
A series of azanaphthoquinone pyrrolo-annelated derivatives attached to basic side chains have been synthesized. The antiproliferative activities of all compounds were evaluated on at least four different cell lines. The effects on cell cycle and intercalation were investigated.
Synthesis of 1,5- and 1,8-diazaanthraquinones by reaction of aminoquinolinequinones with β-dielectrophiles
Marcos, Alicia,Pedregal, Carmen,Avendano, Carmen
, p. 1763 - 1774 (2007/10/02)
Easily obtained amino derivatives of quinoline-5,8-quinone (1 and 2) and 4-methyl-(1H)2,5,8-quinolinetrione (3) react with β-dielectrophiles, affording aminoalkylidenemalonates in a convenient procedure. These compounds cyclise thermally to 1,5-diaza-(1H)4,9,10-anthracenetriones (10 and 19), 1,8-diaza-(1H)4,9,10-anthracenetriones (11 and 20) and 1,5-diaza-(1H, 5H)2,8,9,10-anthracenetetraones (12 and 21). The strategy is less convenient when applied to aromatic precursors. Knorr cyclisation of β-oxoanilides fails in both systems.
