24155-30-4

Basic information

• Product Name: 1-(4-BROMOPHENYL)-2-(1H-IMIDAZOL-1-YL)-1-ETHANONE
• Synonyms: 1-(4-BROMOPHENYL)-2-(1H-IMIDAZOL-1-YL)-1-ETHANONE;1-(4-BROMOPHENYL)-2-(1H-IMIDAZOL-1-YL)-ETHANONE;B90120
• CAS NO: 24155-30-4
• Molecular Formula: C₁₁H₉BrN₂O
• Molecular Weight: 265.11
• Product Categories: API intermediates
• Mol File: 24155-30-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 130-132 °C(Solv: ethanol (64-17-5))
• Boiling Point: 461.38 °C at 760 mmHg
• Flash Point: 232.835 °C
• Appearance: /
• Density: 1.489 g/cm³
• PKA: 6.07±0.10(Predicted)
• CAS DataBase Reference: 1-(4-BROMOPHENYL)-2-(1H-IMIDAZOL-1-YL)-1-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BROMOPHENYL)-2-(1H-IMIDAZOL-1-YL)-1-ETHANONE(24155-30-4)
• EPA Substance Registry System: 1-(4-BROMOPHENYL)-2-(1H-IMIDAZOL-1-YL)-1-ETHANONE(24155-30-4)

Safety Data

• Hazardous Substances Data: 24155-30-4(Hazardous Substances Data)

Usage

General Description

1-(4-Bromophenyl)-2-(1H-imidazol-1-yl)-1-ethanone is a chemical compound with the molecular formula C11H9BrN2O. It is a ketone derivative with a bromophenyl group and an imidazole ring attached to the central ethanone moiety. 1-(4-BROMOPHENYL)-2-(1H-IMIDAZOL-1-YL)-1-ETHANONE may have potential applications in pharmaceuticals, agrochemicals, or materials science due to its versatile chemical structure. It is important to handle this compound with care and follow proper safety protocols, as it may have potential hazards associated with its use. Additional testing and research may be required to fully understand its properties and potential uses.

Upstream product

• 99-90-1 para-bromoacetophenone 
• 288-32-4 1H-imidazole 
• 99-73-0 para-bromophenacyl bromide 

Downstream Products

• 110232-95-6 1,3-bis(4-bromophenyl)-2-(1H-imidazol-1-yl)-prop-2-en-1-one 
• 1206880-91-2 2-(4-bromophenyl)-3-(1H-imidazo-1-yl)-1H-indole 
• 1206880-83-2 N-[1-(4-bromophenyl)-2-(1H-imidazol-1-yl)ethylidene]-N'-phenylhydrazine 
• 134071-42-4 Methanesulfonic acid (2R,4R)-2-(4-bromo-phenyl)-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester 
• 134071-42-4 Methanesulfonic acid (2R,4S)-2-(4-bromo-phenyl)-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester 
• 24155-43-9 1-(4-bromophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol 
• 83086-38-8 cis-2-(4-Bromophenyl)-2-<(1H-imidazol-1-yl)methyl>-1,3-dioxolane-4-methanol 
• 83086-38-8 trans-2-(4-Bromophenyl)-2-<(1H-imidazol-1-yl)methyl>-1,3-dioxolane-4-methanol 

Relevant articles and documents

Novel BuChE-IDO1 inhibitors from sertaconazole: Virtual screening, chemical optimization and molecular modeling studies

In our effort towards the identification of novel BuChE-IDO1 dual-targeted inhibitor for the treatment of Alzheimer's disease (AD), sertaconazole was identified through a combination of structure-based virtual screening followed by MM-GBSA rescoring. Preliminary chemical optimization was performed to develop more potent and selective sertaconazole analogues. In consideration of the selectivity and the inhibitory activity against target proteins, compounds 5c and 5d were selected for the next study. Further modification of compound 5c led to the generation of compound 10g with notably improved selectivity towards BuChE versus AChE. The present study provided us with a good starting point to further design potent and selective BuChE-IDO1 inhibitors, which may benefit the treatment of late stage AD.

Diaryl-containing imidazole compound and preparation method and medical application thereof

The invention discloses a diaryl-containing imidazole compound. The invention further discloses application of the diaryl-containing imidazole compound to preparation of drugs for preventing or treating Alzheimer's disease. The inventor screens butyrylcholine esterase and IDO1 as carriers for inhibiting the activity to evaluate the effect of the diaryl imidazole compound to treat Alzheimer's disease, and finds that the diaryl imidazole compound has good in vitro activity, and can be further developed as a precursor substance for performing the Alzheimer's disease resistant effect by inhibitingthe activity of cholinesterase. (The formula is shown in the description).

ACETYLENIC MICROBIOCIDES

Compounds of formula (I), wherein the other substituents HetAr, A', R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in claim 1, and their use in compositions and methods for the control and/or prevention of microbial infection, particularly fungal infection, in plants and to processes for the preparation of these compounds.