24167-65-5Relevant academic research and scientific papers
Novel cyclic phosphate prodrug approach for cytochrome P450-activated drugs containing an alcohol functionality
Huttunen, Kristiina M.,Maehoenen, Niina,Leppaenen, Jukka,Vepsaelaeinen, Jouko,Juvonen, Risto O.,Raunio, Hannu,Kumpulainen, Hanna,Jaervinen, Tomi,Rautio, Jarkko
, p. 679 - 687 (2007)
Purpose. A cyclic phosphate prodrug of a descriptive molecule containing an alcohol functionality was designed, synthesized and characterized in vitro as a cytochrome P450 (CYP) -selective prodrug. Materials and Methods. To achieve efficient CYP-oxidation
Towards metformin prodrugs
Huttunen, Kristiina M.,Leppaenen, Jukka,Kemppainen, Eeva,Palonen, Piia,Rautio, Jarkko,Jaervinen, Tomi,Vepsaelaeinen, Jouko
experimental part, p. 3619 - 3624 (2009/07/04)
The first examples of possible metformin prodrugs have been synthesized and characterized by spectroscopic methods. These five different types of chemically stable prodrugs were prepared from metformin and the corresponding halogenated promoieties. The products from unstable derivatives were also identified and reasons for the rearrangements are discussed. Georg Thieme Verlag Stuttgart · New York.
Cyclic Organophosphorus Compounds. Part 23. Configurational Assignments in the 4-Phenyl-1,3,2λ5-dioxaphosphorinane Series. X-Ray Molecular Structure of cis-2-Benzylamino-4-phenyl-1,3,2-dioxaphosphorinane 2-oxide.
Edmundson, Ronald S.,Forth, Ian,King, Trevor J.
, p. 976 - 996 (2007/10/02)
The displacement of chlorine from the known diastereomer of 2-chloro-4-phenyl-1,3,2-dioxaphosphorinane 2-oxide by the amines RNH2 (R = PhCH2, Ph, or t-Bu) yields cis-2-amino-4-phenyl-1,3,2-dioxaphosphorinane 2-oxides.Cis-2-benzylamino-4-phenyl-1,3,2-dioxa
