24169-71-9Relevant academic research and scientific papers
ANTIFUNGAL COMPOUNDS OF (ARYLALKYL) AZOLE DERIVATIVES IN THE STRUCTURE OF OXIME ESTER
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, (2015/04/15)
This invention is related to the antifungal compounds having azole structure in Formula (1), and hydrates, solvates, pharmaceutically acceptable salts or geometric isomers thereof. Formula (1)
Design and synthesis of some novel oxiconazole-like carboacyclic nucleoside analogues, as potential chemotherapeutic agents
Rad, Mohammad Navid Soltani,Khalafi-Nezhad, Ali,Behrouz, Somayeh
experimental part, p. 1760 - 1774 (2009/12/06)
The syntheses of some novel carboacyclic nucleosides, 17a-17o, containing oxiconazole-like scaffolds, are described (Schemes 1-3). In this series of carboacyclic nucleosides, pyrimidine as well as purine and other imidazole derivatives were employed as an imidazole successor in oxiconazole. These compounds could be prepared in good yields by using two different strategies (Schemes 1 and 2). Due to Scheme 1, the N-coupling of nucleobases with 2-bromoacetophenones was attained for 18a-18e, and their subsequent oximation affording 19a-19e and finally O-alkylation with diverse alkylating sources resulted in the products 17a-17g, 17n, and 17o. In Scheme 2, use of 2-bromoacetophenone oximes 20, followed by N-coupling of nucleobases, provided 19f-19j whose final O-alkylation produced 17h-17m (Scheme 2). For the rational interpretation of the dominant formation of (E)-oxime ethers rather than (Z)-oxime isomers, PM3 semiempirical quantum-mechanic calculations were discussed and the calculations indicated a lower heat of formation for (E)-isomers.
N-substituted 1-aryl-2-(1H-imidazol-1-yl)-1-ethanamines with broad spectrum in vitro antimycobacterial and antifungal activities
Fioravanti, Rossella,Biava, Mariangela,Porretta, Giulio Cesare,Artico, Marino,Lampis, Giorgio,Deidda, Delia,Pompei, Raffaello
, p. 87 - 97 (2007/10/03)
Novel broad-spectrum in vitro antimycobacterial agents, namely N-(4-biphenyl-1-ylmethyl)-1-aryl-2-(1H-imidazol-1-yl)-1-ethanamines, are described. The new derivatives are also provided with in vitro antifungal activity against a variety of pathogenic fung
