2417-42-7

Usage

Uses

Used in Pharmaceutical Industry:
N-(3-Acetylphenyl)methanesulfonamide is used as a reagent in organic synthesis for the production of pharmaceuticals and other fine chemicals. Its unique chemical structure allows it to be a valuable building block in the synthesis of various drug molecules.
Used in Organic Synthesis:
NAPMSA is used as a reagent in organic synthesis, enabling the formation of a wide range of chemical compounds. Its versatility in chemical reactions makes it a valuable tool for chemists in the development of new materials and compounds.
Used in Antifungal and Antibacterial Applications:
N-(3-Acetylphenyl)methanesulfonamide has been studied for its potential medicinal properties, including its use as an antifungal and antibacterial agent. Its ability to inhibit the growth of certain microorganisms makes it a promising candidate for the development of new antimicrobial drugs.
Used in Photochemical and Photophysical Applications:
NAPMSA has been investigated for its photochemical and photophysical properties, making it a candidate for applications in various industries. Its ability to interact with light and undergo photochemical reactions could be harnessed for the development of new materials and technologies, such as solar cells, sensors, and imaging devices.

Upstream product

• 99-03-6 1-(3-aminophenyl)ethanone 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 61560-93-8 2-(3-Mesylaminophenyl)glyoxylic acid 
• 2065-04-5 2-bromo-1-[3-[(methylsulfonyl)amino]phenyl]ethanone 
• 1477503-64-2 N-(3-(6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)methanesulfonamide 
• 1428986-90-6 C₂₃H₂₅N₅O₂S 
• 1428986-89-3 C₂₀H₁₈N₄O₃S 
• 1428986-88-2 C₂₀H₁₈N₄O₄S 
• 1428986-86-0 C₂₀H₁₈N₄O₃S 
• 1428986-85-9 C₂₁H₂₀N₄O₄S 
• 1428986-84-8 C₂₀H₁₈N₄O₃S 
• 1016774-07-4 C₉H₁₂N₂O₃S 
• 801150-73-2 N-[3-(2-Amino-acetyl)-phenyl]-methanesulfonamide 
• 79406-64-7 N-[3-(2-Amino-1-hydroxy-ethyl)-phenyl]-methanesulfonamide 

Relevant academic research and scientific papers

1,3,4-OXADIAZOLE SULFONAMIDE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to novel compounds represented by the formula I having histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. (I) The novel compounds, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases.

Synthesis and biological evaluation of glucagon-like peptide-1 receptor agonists

In this study, a series of fused-heterocyclic derivatives were systematically designed and synthesized using an efficient route, and evaluated in terms of GLP-1R agonist activity. We employed short synthetic steps and reactions that are tolerant of the presence of various functional groups and suitable for parallel operations to enable the rapid generation of libraries of diverse and structurally complex small molecules. Of the compounds synthesized, 3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a] pyridin-2-yl)phenyl methanesulfonate (8e) was the most potent agonist with an EC50 of 7.89 μM, and thus is the compound with the greatest potential for application. These findings represent a valuable starting point for the design and discovery of small-molecule GLP-1R agonists that can be administered orally.

Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening

The design through energy-based pharmacophore virtual screening has led to aminocyanopyridine derivatives as efficacious new inhibitors of Hsp90. The synthesized compounds showed a good affinity for the Hsp90 ATP binding site in the competitive binding as

Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)

A novel series of inhibitors for mitogen activated protein kinase-activated protein kinase 2 (MK-2) are reported. These squarate based inhibitors were identified via a high-throughput screen. An MK2 co-structure with the starting ligand was obtained and a structure based approach was followed to optimize potency and selectivity.

Catecholamine surrogates useful as β3 agonists

Compounds of the formula STR1 or pharmaceutically acceptable salts thereof wherein: A is a bond, --(CH 2) n -- or --CH(B)--, where n is an integer of 1 to 3 and B is --CN, --CON(R 9)R 9'' or --CO 2 R 7 ;R 1 is lower alkyl, aryl or arylalkyl;R 2 is hydrogen, hydroxy, alkoxy, --CH 2 OH, cyano, --C(O)OR 7, --CO 2 H, --CONH 2, tetrazole, --CH 2 NH 2 or halogen; STR2 R 3 is hydrogen, alkyl, heterocycle or R 4 is hydrogen, alkyl or B;R 5, R 5'', R 8, R 8'' or R 8"" are independently hydrogen, alkoxy, lower alkyl, halogen, --OH, --CN, --(CH 2) n NR 6 COR 7, --CON(R 6)R 6'', --CON(R 6)OR 6'', --CO 2 R 6, --SR 7, --SOR 7, --SO 2 R 7, --N(R 6)SO 2 R 1, --N(R 6)R 6'', --NR 6 COR 7, --OCH 2 CON(R 6)R 6'', --OCH 2 CO 2 R 7 or aryl; orR 5 and R 5'' or R 8 and R 8'' may together with the carbon atoms to which they are attached form an aryl or heterocycle;R 6 and R 6'' are independently hydrogen or lower alkyl; andR 7 is lower alkyl;R 9 is hydrogen, lower alkyl, alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl; or R 9 and R 9'' may together with the nitrogen atom to which they are attached form a heterocycle; with the proviso that when A is a bond or --(CH 2) n and R 3 is hydrogen or unsubstituted alkyl, then R 4 is B or substituted alkyl. These compounds are beta 3 adrenergic receptor agonists and are useful, therefore for example, in the treatment of diabetes, obesity and gastrointestinal diseases.

Substituent effects in infrared spectroscopy-VII. Meta and para substituted methanesulphonanilides

Substituent effects on the NH frequencies of the conformers of methanesulphonanilides, their cyclic dimers and their hydrogen bonded complexes with acetonitrile have been analysed by means of the Hammet equation.An electron-withdrawing substituent may either increase or decrease ν(NH) in the XC6H4NHY series according to the electronic nature of the Y group.This can be explained by the non-monotonic dependence of the NH stretching frequency on the ionic character of the NH bond.