241815-02-1

Basic information

• Product Name: toluene-4-sulfonic acid 3-(3-{[2-(2-cyano-ethylsulfanyl)-phenyl]-methyl-carbamoyl}-propyl)-1-hydroxy-2,2,4-trimethyl-cyclohex-3-enylmethyl ester
• CAS NO: 241815-02-1
• Molecular Weight: 584.801
• Mol File: 241815-02-1.mol

Chemical Properties

• CAS DataBase Reference: toluene-4-sulfonic acid 3-(3-{[2-(2-cyano-ethylsulfanyl)-phenyl]-methyl-carbamoyl}-propyl)-1-hydroxy-2,2,4-trimethyl-cyclohex-3-enylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: toluene-4-sulfonic acid 3-(3-{[2-(2-cyano-ethylsulfanyl)-phenyl]-methyl-carbamoyl}-propyl)-1-hydroxy-2,2,4-trimethyl-cyclohex-3-enylmethyl ester(241815-02-1)
• EPA Substance Registry System: toluene-4-sulfonic acid 3-(3-{[2-(2-cyano-ethylsulfanyl)-phenyl]-methyl-carbamoyl}-propyl)-1-hydroxy-2,2,4-trimethyl-cyclohex-3-enylmethyl ester(241815-02-1)

Safety Data

• Hazardous Substances Data: 241815-02-1(Hazardous Substances Data)

Upstream product

• 241815-01-0 4-(2,2,6,6,8-pentamethyl-1,3-dioxa-spiro[4.5]dec-7-en-7-yl)-butyric acid 
• 241815-00-9 C₁₇H₂₇NO₃ 
• 241814-99-3 C₁₇H₂₆O₃ 
• 131613-90-6 5',5',8'a-trimethyl-3',5',8',8'a-tetrahydro-spiro<1,3-dioxolane-2,1'(2'H)naphthalene>-6'(7'H)-one 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant articles and documents

A synthesis of taxanes by lactam-sulfoxide ring contraction and intramolecular pinacol coupling

A synthesis of the taxane ring system is described. The A-ring moiety 5, containing the carbons for construction of the Bring, was prepared from Wieland-Miescher ketone via Beckmann fragmentation of the oxime 10. The B- ring was formed by means of 12-membered lactam-sulfoxide ring contraction. The formation of the C-ring was carried out by aldol condensation of the resulting AB-ring moiety 3 followed by intramolecular pinacol coupling to give the tricyclic diol 23.