24182-10-3Relevant academic research and scientific papers
Progress toward the synthesis of piperazimycin A: exploration of the synthesis of γ-hydroxy and γ-chloropiperazic acids
Phillip Kennedy,Brogan, John T.,Lindsley, Craig W.
, p. 4116 - 4118 (2008/09/21)
Employing Hamada's chemistry with MAOS optimization of several steps, an expedient route to key (3S,5S)- and (3R,5R)-γ-hydroxy and (3R,5S)-γ-chloropiperazic acids, was developed en route to a total synthesis of piperazimycin A.
Monamycin synthetic studies. Pt 1. An enantiospecific total synthesis of (3S,5S)-5-hydroxypiperazic acid from D-mannitol
Hale, Karl J.,Jogiya, Neha,Manaviazar, Soraya
, p. 7163 - 7166 (2007/10/03)
The first enantiospecific total synthesis of (3S,5S)-hydroxypiperazic acid 1 is described. The synthesis begins from D-mannitol and exploits a tandem electrophilic hydrazination/nucleophilic cyclisation reaction to assemble the hexahydropyridazine ring system.
