31321-66-1

Upstream product

• 70-34-8 2,4-Dinitrofluorobenzene 
• 24182-10-3 5-hydroxy-hexahydro-pyridazine-3-carboxylic acid 
• 214354-03-7 (3S,5S)-3-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-5-benzyloxy-tetrahydro-pyridazine-1,2-dicarboxylic acid di-tert-butyl ester 
• 214354-11-7 (3S,5S)-5-Benzyloxy-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester 
• 214354-12-8 (3S,5S)-5-Acetoxy-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester 
• 214354-19-5 (3S,5S)-5-Hydroxy-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester 
• 400019-84-3 (3S,5S)-5-Acetoxy-1-(2,4-dinitro-phenyl)-hexahydro-pyridazine-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Monamycin synthetic studies. Pt 1. An enantiospecific total synthesis of (3S,5S)-5-hydroxypiperazic acid from D-mannitol

The first enantiospecific total synthesis of (3S,5S)-hydroxypiperazic acid 1 is described. The synthesis begins from D-mannitol and exploits a tandem electrophilic hydrazination/nucleophilic cyclisation reaction to assemble the hexahydropyridazine ring system.