24182-11-4

Basic information

• Product Name: (R)-PIPERAZINE-2-CARBOXYLIC ACID
• Synonyms: R-PCA;(R)-2-PIPERAZINECARBOXYLIC ACID;2-PIPERAZINECARBOXYLIC ACID, (2R)-;2-(R)-PIPERAZINE CARBOXYLIC ACID;(2R)-PIPERAZINE-2-CARBOXYLIC ACID;3-PYRIDAZINECARBOXYLIC ACID, HEXAHYDRO-, (3R)-;R(+)-Piperidazine-2-carboxylic acid
• CAS NO: 24182-11-4
• Molecular Formula: C₅H₁₀N₂O₂
• Molecular Weight: 130.15
• Mol File: 24182-11-4.mol

Chemical Properties

• Boiling Point: 313.622 °C at 760 mmHg
• Flash Point: 143.474 °C
• Appearance: White or light yellow crystalline powder
• Density: 1.175 g/cm³
• PKA: 3.37±0.20(Predicted)
• CAS DataBase Reference: (R)-PIPERAZINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-PIPERAZINE-2-CARBOXYLIC ACID(24182-11-4)
• EPA Substance Registry System: (R)-PIPERAZINE-2-CARBOXYLIC ACID(24182-11-4)

Safety Data

• Hazardous Substances Data: 24182-11-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(R)-PIPERAZINE-2-CARBOXYLIC ACID is used as an intermediate in the synthesis of various pharmaceuticals and research chemicals. Its unique chiral properties make it a valuable building block in the production of active pharmaceutical ingredients.
Used in Drug Discovery and Development:
(R)-PIPERAZINE-2-CARBOXYLIC ACID is employed as a key component in the development of drugs targeting central nervous system disorders and cancer treatment. Its biological activity and versatile chemical structure contribute to the creation of novel therapeutic agents with improved efficacy and selectivity.

Upstream product

• 72064-50-7 (+/-) hexahydropyridazine-3-carboxylic acid hydrochloride 
• 1219380-72-9 N,N'-di-tert-butoxycarbonylpiperazic acid 
• 1400276-80-3 (4aS,10aR,13S,19aR,21aS,26bR,27aS,30S)-24-chloro-2,3,4,4a,8,9,10,10a,12,13,17,18,19,19a,22,26b,27,27a,29,30-icosahydro-26b-hydroxy-12,13-dimethyl-30-(2-methylpropyl)-7H,21aH-tripyridazino[1’’,6’’:10’,11’;1’’’,6’’’:16’,17’;1’’’’,6’’’’:7’,8’] [1,4,7,10,13,16]hexaazacyclooctadecino[1’,2’:1,5]pyrrolo[2,3-b]indole-5,11,14,20,28,31(1H,16H)hexone 

Downstream Products

• 31481-38-6 N^α,N^δ-Bis(2,4-dinitrophenyl)-D-ornithin 

Relevant articles and documents

Synthesis of cyclic α-hydrazino acids

Synthesis of five-, six-, seven-, eight-, and nine-membered cyclic α-hydrazino acids from a common starting material 'diethylmalonate' with 26, 16, 34, 13.5, and 13.33% overall yields is described. Sequential allylation or homoallylation and electrophilic amination followed by cyclization gave the desired rings. The methyl esters of eight- and nine-membered rings were synthesized by RCM and the corresponding free acids were generated after hydrolysis in the presence of 1 M BBr3 solution in DCM.

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Chloptosin, an apoptosis-inducing dimeric cyclohexapeptide produced by Streptomyces

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