1219380-72-9Relevant articles and documents
Improved synthesis of cyclic α -hydrazino acids of five- to nine-membered rings and optical resolution of 5,6,7-membered ring hydrazino acids
Duttagupta, Indranil,Goswami, Koushik,Chatla, Prathyusha,Sinha, Surajit
supporting information, p. 2510 - 2519 (2014/08/05)
GRAPHICAL ABSTRACT Synthesis of cyclic α-hydrazino acids of five- to nine-membered rings has been described. Di-tert-butyl or dibenzyl malonate was used as starting materials instead of diethyl malonate, which was used in our first report. Deprotection of
Synthesis of cyclic α-hydrazino acids
Duttagupta, Indranil,Goswami, Koushik,Sinha, Surajit
experimental part, p. 8347 - 8357 (2012/09/21)
Synthesis of five-, six-, seven-, eight-, and nine-membered cyclic α-hydrazino acids from a common starting material 'diethylmalonate' with 26, 16, 34, 13.5, and 13.33% overall yields is described. Sequential allylation or homoallylation and electrophilic amination followed by cyclization gave the desired rings. The methyl esters of eight- and nine-membered rings were synthesized by RCM and the corresponding free acids were generated after hydrolysis in the presence of 1 M BBr3 solution in DCM.