24186-38-7

Usage

Uses

Used in Organic Synthesis:
p-Methyl-cinnamoyl Azide is used as a synthetic building block for the creation of various organic compounds. Its azide functional group allows for a range of reactions, such as the formation of amines, nitriles, and other nitrogen-containing compounds, which are essential in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, p-Methyl-cinnamoyl Azide is used as a key intermediate in the synthesis of various drug molecules. Its unique reactivity and structural properties enable the development of novel therapeutic agents with improved efficacy and selectivity.
Used in Agrochemical Industry:
p-Methyl-cinnamoyl Azide is also employed in the agrochemical industry for the synthesis of new pesticides and other crop protection agents. Its versatility in organic synthesis allows for the development of innovative compounds with enhanced biological activity and reduced environmental impact.
Used in Research and Development:
In the field of research and development, p-Methyl-cinnamoyl Azide serves as a valuable tool for chemists to explore new reaction pathways and develop innovative synthetic strategies. Its unique properties make it an attractive candidate for the design and synthesis of complex organic molecules with potential applications in various industries.

Upstream product

• 1866-39-3 4-methylcinnamic acid 
• 895160-08-4 p-methylcinnamoyl benzotriazolyl amide 

Downstream Products

• 26829-47-0 7-methylisoquinolin-1(2H)-one 

Relevant academic research and scientific papers

FeCl36H2O-Catalyzed acceleration of the acylation of sodium azide with n-acylbenzotriazoles

Catalyzed by ferric chloride hexahydrate (FeCl36H2O), the acylation of sodium azide with N-acylbenzotriazoles was greatly accelerated in a mixed solvent of acetone and water. Thus, good to excellent yields of a variety of acyl azides were obtained at room temperature in a short time. Furthermore, because of the complete conversion of N-acylbenzotriazoles and the easy removal of the by-product, purification by column chromatography was no longer required, which made the protocol suitable for large-scale preparation.

Simple and facile method for the preparation of vinyl azides

A synthetic utility of [bis(trifluoroacetoxy)iodo]benzene on α,β-unsaturated carboxylic acid is described. This is the first example of preparation of vinyl azide using α,β-unsaturated carboxylic acids directly by using hypervalent iodine reagent. The adv

Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin

The compounds of the present invention are represented by the chemical structure found in Formula (I): wherein: the carbon atom designated * is in the R or S configuration; and X is a fused bicyclic carbocycle or heterocycle selected from the group consisting of benzofuranyl, benzo[b]thiophenyl, benzoisothiazolyl, benzoisoxazolyl, indazolyl, indolyl, isoindolyl, indolizinyl, benzoimidazolyl, benzooxazolyl, benzothiazolyl, benzotriazolyl, imidazo[1,2-a]pyridinyl, pyrazolo[1,5-a]pyridinyl, [1,2,4]triazolo[4,3-a]pyridinyl, thieno[2,3-b]pyridinyl, thieno[3,2-b]pyridinyl, 1H-pyrrolo[2,3-b]pyridinyl, indenyl, indanyl, dihydrobenzocycloheptenyl, tetrahydrobenzocycloheptenyl, dihydrobenzothiophenyl, dihydrobenzofuranyl, indolinyl, naphthyl, tetrahydronaphthyl, quinolinyl, isoquinolinyl, 4H-quinolizinyl, 9aH-quinolizinyl, quinazolinyl, cinnolinyl, phthalazinyl, quinoxalinyl, benzo[1,2,3]triazinyl, benzo[1,2,4]triazinyl, 2H-chromenyl, 4H-chromenyl, and a fused bicyclic carbocycle or fused bicyclic heterocycle optionally substituted with substituents (1 to 4 in number) as defined in R14; with R1, R2, R3, R4, R5, R6, R7, R8, and R14 defined herein.