24186-50-3Relevant academic research and scientific papers
Synthesis of N-Acetyl-1,2-didehydrodopamine. A Key Intermediate Involved in Sclerotization of Insect Cuticule
Ramamurthy, B.,Sugumaran, M.
, p. 523 - 524 (2007/10/02)
The synthesis of N-acetyl-1,2-didehydrodopamine (6; N-acetyl-3,4-dihydroxystyrylamine) was accomplished by demethylation of N-acetyl-3,4-dimethoxystyrylamine (5), formed by sequential treatment of 3,4-dimethoxycinnamic acid (1) with thionyl chloride, sodi
NICKEL-PHOSPHINE COMPLEX-CATALYZED GRIGNARD COUPLING-II; GRIGNARD COUPLING OF HETEROCYCLIC COMPOUNDS
Tamao, K.,Kodama, S.,Nakajima, I.,Kumada, M.,Minato, A.,Suzuki, K.
, p. 3347 - 3354 (2007/10/02)
A general, versatile method for alkylation and arylation of haloheterocyclic compounds is reported.In the presence of a catalytic quantity of , where dppp stands for Ph2P(CH2)3PPh2, bromothiophenes, halopyridines, haloquinoline, and haloisoquinolines reacted with alkyl and aryl Grignard reagents at room temperature or at ether refluxing temperature to give the cross-coupling products.The coupling reactions has been applied to the synthesis of isoquinoline alkaloids.Reactivities of 2-thienyl and 2-pyridyl Grignard reagents have also been examined.
