21560-29-2

Usage

Uses

Used in Pharmaceutical Industry:
6,7-DiMethoxy-1-chloroisoquinoline is used as a chemical intermediate for the development of new drugs and medicinal compounds. Its unique structure and functional groups may offer advantages in the synthesis of pharmaceutical agents, contributing to the discovery of novel therapeutics.
Used in Organic Synthesis:
6,7-DiMethoxy-1-chloroisoquinoline serves as a building block in organic synthesis, allowing chemists to create a variety of complex organic molecules. Its presence of methoxy and chlorine substituents can facilitate the formation of diverse chemical products.
Used in Chemical Research:
6,7-DiMethoxy-1-chloroisoquinoline is utilized in chemical research to study the properties and reactivity of isoquinoline derivatives. Further investigation is required to fully understand its characteristics, potential applications, and to explore its use in the development of new chemical processes and materials.

Upstream product

• 16101-63-6 6,7-dimethoxy-isoquinolin-1-ol 
• 15248-39-2 6,7-dimethoxyisoquinoline 
• 2316-26-9 3,4-dimethoxycinnamic acid 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 24186-50-3 4-((E)-2-Isocyanato-vinyl)-1,2-dimethoxy-benzene 
• 24186-43-4 (E)-3-(3,4-Dimethoxy-phenyl)-acryloyl azide 
• 493-49-2 6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one 
• 17889-63-3 N-<2-(3,4-Dimethoxyphenyl)ethyl>carbamidsaeureethylester 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 16101-63-6 6,7-dimethoxyisoquinoline-1(2H)-one 
• 40788-74-7 6,7-dimethoxyisoquinoline 2-oxide 

Downstream Products

• 15547-50-9 6,7-dimethoxy-1-(3,4-dimethoxyphenyl)-isoquinoline 
• 85932-64-5 1-<2-(4-clorophenyl)ethyl>-6,7-dimethoxyisoquinoline 
• 1613479-64-3 1-(4-fluorophenoxy)-6,7-dimethoxyisoquinoline 
• 1613479-58-5 C₁₇H₁₃F₂NO₃ 

Relevant academic research and scientific papers

NHC-Organocatalyzed CAr?O Bond Cleavage: Mild Access to 2-Hydroxybenzophenones

A Truce–Smiles rearrangement of acyl-anion equivalents generated by N-heterocyclic carbene (NHC) catalysis has been achieved. The developed method includes CAr?O, CAr?S, or CAr?N bond cleavage for the formation of a CAr?C bond and enables access to 2-hydroxybenzophenones, an important structural motif that is present in several bioactive natural products. By utilizing this procedure, the alkaloid taxilamine was synthesized in three steps. DFT calculations and control experiments support a classical SNAr mechanism with a catalyst-bound Meisenheimer-type intermediate. The method features mild reaction conditions, excellent functional-group tolerance, and a broad substrate scope, including various classes of (hetero)arenes.

A highly practical and convenient halogenation of fused heterocyclic N-oxides

A novel, simple and practical method for the regioselective halogenation of fused heterocyclic N-oxides has been developed. It employs Vilsmeier reagent, generated in situ by POX3and DMF, as both the activating agent and the nucleophilic halide source. The method is amenable across a broad range of substrates, including quinolines, isoquinolines and the diazine N-oxides, possessing a variety of substitution patterns. Furthermore, all of the reagents associated are cheap and easy to obtain. The potential extension of this method to a one-pot oxidation/halogenation sequence that obviates the need for isolation of the N-oxide intermediates is also presented.

Discovery of a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine and a 1-aryloxyisoquinoline series of TRPA1 antagonists

A series of TRPA1 antagonists is described having a 4-aryloxy-1H-pyrrolo[3, 2-c]pyridine or a 1-aryloxyisoquinoline scaffold. These compounds have high ligand efficiency and favorable physical properties and may thus serve as scaffolds for further optimization.

Discovery of a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine and a 1-aryloxyisoquinoline series of TRPA1 antagonists

A series of TRPA1 antagonists is described having a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine or a 1-aryloxyisoquinoline scaffold. These compounds have high ligand efficiency and favorable physical properties and may thus serve as scaffolds for further optimization.

NICKEL-PHOSPHINE COMPLEX-CATALYZED GRIGNARD COUPLING-II; GRIGNARD COUPLING OF HETEROCYCLIC COMPOUNDS

A general, versatile method for alkylation and arylation of haloheterocyclic compounds is reported.In the presence of a catalytic quantity of , where dppp stands for Ph2P(CH2)3PPh2, bromothiophenes, halopyridines, haloquinoline, and haloisoquinolines reacted with alkyl and aryl Grignard reagents at room temperature or at ether refluxing temperature to give the cross-coupling products.The coupling reactions has been applied to the synthesis of isoquinoline alkaloids.Reactivities of 2-thienyl and 2-pyridyl Grignard reagents have also been examined.