24188-40-7

Usage

Uses

Used in Pharmaceutical Industry:
N2-isopropylpyridine-2,3-diamine is used as a key intermediate in the synthesis of pharmaceuticals for its ability to form stable complexes with other molecules, enhancing the drug's efficacy and bioavailability.
Used in Organic Synthesis:
In the field of organic synthesis, N2-isopropylpyridine-2,3-diamine serves as a valuable building block for the creation of complex organic molecules, leveraging its strong basic properties and reactive functional groups.
Used in Chemical Industry:
N2-isopropylpyridine-2,3-diamine is utilized in the development of various chemical compounds, taking advantage of its unique structure to impart specific properties to the final products, such as improved stability or reactivity.
Used in Catalyst Design:
N2-isopropylpyridine-2,3-diamine's basic nature and structural features make N2-isopropylpyridine-2,3-diamine a candidate for the design of catalysts in various chemical reactions, potentially enhancing reaction rates and selectivity.
Used in Material Science:
N2-isopropylpyridine-2,3-diamine can be incorporated into the development of new materials, such as polymers or coatings, where its strong basic properties and pyridine ring may contribute to desired material characteristics, like adhesion or corrosion resistance.

InChI:InChI=1/C8H13N3/c1-6(2)11-8-7(9)4-3-5-10-8/h3-6H,9H2,1-2H3,(H,10,11)

Upstream product

• 19755-53-4 2-bromo-3-nitropyridine 
• 26820-67-7 2-isopropylamino-3-nitropyridine 

Relevant academic research and scientific papers

C?H Methylation of Iminoamido Heterocycles with Sulfur Ylides**

The direct methylation of N-heterocycles is an important transformation for the advancement of pharmaceuticals, agrochemicals, functional materials, and other chemical entities. Herein, the unprecedented C(sp2)-H methylation of iminoamido heterocycles as nucleoside base analogues is described. Notably, trimethylsulfoxonium salt was employed as a methylating agent under aqueous conditions. A wide substrate scope and excellent level of functional-group tolerance were attained. Moreover, this method can be readily applied to the site-selective methylation of azauracil nucleosides. The feasibility of gram-scale reactions and various transformations of the products highlight the synthetic potential of the developed method. Combined deuterium-labeling experiments aided the elucidation of a plausible reaction mechanism.

Imidazopyridines: A novel class of hNav1.7 channel blockers

A series of imidazopyridines were evaluated as potential sodium channel blockers for the treatment of neuropathic pain. Several members were identified with good hNav1.7 potency and excellent rat pharmacokinetic profiles. Compound 4 had good efficacy (52% and 41% reversal of allodynia at 2 and 4 h post-dose, respectively) in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain when dosed orally at 10 mg/kg.