26820-67-7

Basic information

• Product Name: N-isopropyl-3-nitropyridin-2-amine
• Synonyms: N-isopropyl-3-nitropyridin-2-amine
• CAS NO: 26820-67-7
• Molecular Formula: C₈H₁₁N₃O₂
• Molecular Weight: 181.19184
• Mol File: 26820-67-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 303.183 °C at 760 mmHg
• Flash Point: 137.161 °C
• Appearance: /
• Density: 1.23 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: 2-8°C
• PKA: 2.70±0.10(Predicted)
• CAS DataBase Reference: N-isopropyl-3-nitropyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-isopropyl-3-nitropyridin-2-amine(26820-67-7)
• EPA Substance Registry System: N-isopropyl-3-nitropyridin-2-amine(26820-67-7)

Safety Data

• Hazardous Substances Data: 26820-67-7(Hazardous Substances Data)

Usage

General Description

N-isopropyl-3-nitropyridin-2-amine is a chemical compound with the molecular formula C8H11N3O2. It is a derivative of pyridine and contains a nitro group and an amine group. The isopropyl group is attached to the nitrogen atom, giving the compound its name. It is commonly used in the synthesis of various organic compounds and pharmaceuticals. The presence of the nitro and amine groups gives the compound potential for use in the development of drugs and biologically active molecules. Overall, N-isopropyl-3-nitropyridin-2-amine has a range of potential applications in the fields of chemistry and pharmaceuticals.

InChI:InChI=1/C8H11N3O2/c1-6(2)10-8-7(11(12)13)4-3-5-9-8/h3-6H,1-2H3,(H,9,10)

Upstream product

• 19755-53-4 2-bromo-3-nitropyridine 
• 75-31-0 isopropylamine 
• 5470-18-8 2-Chloro-3-nitropyridine 

Downstream Products

• 24188-40-7 3-amino-2-isopropylamino-pyridine 

Relevant articles and documents

Synthesis of a new series of imidazo-[1,5-a]pyrido[2,3-e]pyrazines as potential ligands for the GABA receptor complex

Starting from 2-chloro-3-nitropyridine, 2-isopropyl-1,4-dihydropyrido[2,3-b]pyrazin-2(3H),3-dione was synthesized. This compound was reacted with potassium tert-butoxide and diethyl chlorophosphate to afford an intermediate dihydropyrido[2,3-b]pyrazin-2-y

Imidazopyridines: A novel class of hNav1.7 channel blockers

A series of imidazopyridines were evaluated as potential sodium channel blockers for the treatment of neuropathic pain. Several members were identified with good hNav1.7 potency and excellent rat pharmacokinetic profiles. Compound 4 had good efficacy (52% and 41% reversal of allodynia at 2 and 4 h post-dose, respectively) in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain when dosed orally at 10 mg/kg.