26820-67-7

Usage

Uses

Used in Pharmaceutical Industry:
N-isopropyl-3-nitropyridin-2-amine is used as a key intermediate in the synthesis of various pharmaceuticals for its potential to form biologically active molecules. The presence of the nitro and amine groups allows for further chemical modifications, facilitating the development of new drugs with specific therapeutic properties.
Used in Organic Synthesis:
In the field of organic chemistry, N-isopropyl-3-nitropyridin-2-amine serves as a versatile building block for the creation of a wide range of organic compounds. Its reactivity and functional groups make it suitable for use in various synthetic pathways, contributing to the advancement of chemical research and the discovery of novel compounds with potential applications.
Overall, N-isopropyl-3-nitropyridin-2-amine's unique structure and properties position it as a valuable compound in both the pharmaceutical and chemical industries, with a broad spectrum of potential applications in the development of new drugs, organic compounds, and other related areas.

InChI:InChI=1/C8H11N3O2/c1-6(2)10-8-7(11(12)13)4-3-5-9-8/h3-6H,1-2H3,(H,9,10)

Upstream product

• 5470-18-8 2-Chloro-3-nitropyridine 
• 75-31-0 isopropylamine 
• 19755-53-4 2-bromo-3-nitropyridine 

Downstream Products

• 24188-40-7 3-amino-2-isopropylamino-pyridine 

Relevant academic research and scientific papers

Synthesis of a new series of imidazo-[1,5-a]pyrido[2,3-e]pyrazines as potential ligands for the GABA receptor complex

Starting from 2-chloro-3-nitropyridine, 2-isopropyl-1,4-dihydropyrido[2,3-b]pyrazin-2(3H),3-dione was synthesized. This compound was reacted with potassium tert-butoxide and diethyl chlorophosphate to afford an intermediate dihydropyrido[2,3-b]pyrazin-2-y

C?H Methylation of Iminoamido Heterocycles with Sulfur Ylides**

The direct methylation of N-heterocycles is an important transformation for the advancement of pharmaceuticals, agrochemicals, functional materials, and other chemical entities. Herein, the unprecedented C(sp2)-H methylation of iminoamido heterocycles as nucleoside base analogues is described. Notably, trimethylsulfoxonium salt was employed as a methylating agent under aqueous conditions. A wide substrate scope and excellent level of functional-group tolerance were attained. Moreover, this method can be readily applied to the site-selective methylation of azauracil nucleosides. The feasibility of gram-scale reactions and various transformations of the products highlight the synthetic potential of the developed method. Combined deuterium-labeling experiments aided the elucidation of a plausible reaction mechanism.

Imidazopyridines: A novel class of hNav1.7 channel blockers

A series of imidazopyridines were evaluated as potential sodium channel blockers for the treatment of neuropathic pain. Several members were identified with good hNav1.7 potency and excellent rat pharmacokinetic profiles. Compound 4 had good efficacy (52% and 41% reversal of allodynia at 2 and 4 h post-dose, respectively) in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain when dosed orally at 10 mg/kg.