24188-72-5

Basic information

• Product Name: 5-METHYL-2H-ISOQUINOLIN-1-ONE
• Synonyms: 5-METHYL-2H-ISOQUINOLIN-1-ONE;5-methylisoquinolin-1(2H)-one;5-Methyl-2H-Isoquinoline-1-one;5-Methylisoquinolin-1-ol;5-Methylisoquinolin-1(2H);5-methyl-1,2-dihydroisoquinolin-1-one
• CAS NO: 24188-72-5
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18
• Mol File: 24188-72-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 400.477°C at 760 mmHg
• Flash Point: 235.103°C
• Appearance: /
• Density: 1.15g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.12±0.20(Predicted)
• CAS DataBase Reference: 5-METHYL-2H-ISOQUINOLIN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-2H-ISOQUINOLIN-1-ONE(24188-72-5)
• EPA Substance Registry System: 5-METHYL-2H-ISOQUINOLIN-1-ONE(24188-72-5)

Safety Data

• Hazardous Substances Data: 24188-72-5(Hazardous Substances Data)

Usage

General Description

5-Methyl-2H-isoquinolin-1-one is a chemical compound with the molecular formula C10H9NO. It belongs to the class of isoquinolinones, which are heterocyclic compounds containing a fusion of a benzene ring and a pyridine ring. 5-METHYL-2H-ISOQUINOLIN-1-ONE is commonly used in the synthesis of pharmaceuticals and natural products. It exhibits a variety of biological activities, including anticonvulsant and antitumor properties. Additionally, it is also used as a building block in the synthesis of other organic compounds. The chemical structure of 5-Methyl-2H-isoquinolin-1-one and its derivatives have attracted much attention in medicinal chemistry due to their potential as therapeutic agents.

InChI:InChI=1/C10H9NO/c1-7-3-2-4-9-8(7)5-6-11-10(9)12/h2-6H,1H3,(H,11,12)

Upstream product

• 1711-06-4 3-Methylbenzoyl chloride 
• 99-04-7 m-Toluic acid 
• 263159-64-4 2-bromo-3-methyl-benzonitrile 
• 101421-85-6 2-bromo-3-methylbenzamide 
• 131002-06-7 2-ethenyl-3-methylbenzamide 
• 133933-18-3 N-(3-toluoyl)aminoacetaldehyde dimethyl acetal 
• 872509-52-9 O-methylcinnamoyl azide 

Downstream Products

• 129075-56-5 PD128763 
• 1384249-50-6 (1-(4-fluorophenoxy)-5-methylisoquinolin-4-yl)(morpholino)methanone 
• 1384248-95-6 (1-((3-chlorophenyl)amino)-5-methylisoquinolin-4-yl)(morpholino)methanone 
• 444898-38-8 C₃₆H₂₉NO₈ 

Relevant articles and documents

Synthesis of Isoquinolones by Sequential Suzuki Coupling of 2-Halobenzonitriles with Vinyl Boronate Followed by Cyclization

A novel, facile, and expeditious two-step synthesis of 3,4-unsubstituted isoquinolin-1(2H)-ones from a Suzuki cross-coupling between 2-halobenzonitriles and commercially available vinyl boronates followed by platinum-catalyzed nitrile hydrolysis and cyclization is described.

CANNABINOID RECEPTOR MODULATORS

Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors. Methods of treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors of Formula (I).

HEPATITIS C VIRUS INHIBITORS

Hepatitis C virus inhibitors are disclosed having the general formula:(I) wherein R1, R2, R3, R', B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds toinhibit HCV are also disclosed.