24188-72-5

Usage

Uses

Used in Pharmaceutical Synthesis:
5-METHYL-2H-ISOQUINOLIN-1-ONE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Natural Product Synthesis:
In the realm of natural product synthesis, 5-METHYL-2H-ISOQUINOLIN-1-ONE is utilized as a building block, facilitating the creation of complex organic molecules that can exhibit biological activity.
Used in Medicinal Chemistry Research:
5-METHYL-2H-ISOQUINOLIN-1-ONE is employed as a research compound in medicinal chemistry, where its structure and derivatives are studied for their potential as therapeutic agents, particularly due to their anticonvulsant and antitumor properties.
Used in Organic Chemistry:
As a versatile organic compound, 5-METHYL-2H-ISOQUINOLIN-1-ONE is used in organic chemistry for the synthesis of other complex organic compounds, contributing to the advancement of chemical knowledge and the development of novel materials.

InChI:InChI=1/C10H9NO/c1-7-3-2-4-9-8(7)5-6-11-10(9)12/h2-6H,1H3,(H,11,12)

Upstream product

• 1711-06-4 3-Methylbenzoyl chloride 
• 99-04-7 m-Toluic acid 
• 263159-64-4 2-bromo-3-methyl-benzonitrile 
• 101421-85-6 2-bromo-3-methylbenzamide 
• 872509-52-9 O-methylcinnamoyl azide 
• 133933-18-3 N-(3-toluoyl)aminoacetaldehyde dimethyl acetal 
• 131002-06-7 2-ethenyl-3-methylbenzamide 

Downstream Products

• 444898-38-8 C₃₆H₂₉NO₈ 
• 1384249-50-6 (1-(4-fluorophenoxy)-5-methylisoquinolin-4-yl)(morpholino)methanone 
• 1384248-95-6 (1-((3-chlorophenyl)amino)-5-methylisoquinolin-4-yl)(morpholino)methanone 
• 129075-56-5 PD128763 

Relevant academic research and scientific papers

Synthesis of Isoquinolones by Sequential Suzuki Coupling of 2-Halobenzonitriles with Vinyl Boronate Followed by Cyclization

A novel, facile, and expeditious two-step synthesis of 3,4-unsubstituted isoquinolin-1(2H)-ones from a Suzuki cross-coupling between 2-halobenzonitriles and commercially available vinyl boronates followed by platinum-catalyzed nitrile hydrolysis and cyclization is described.

CANNABINOID RECEPTOR MODULATORS

Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors. Methods of treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors of Formula (I).

CANNABINOID RECEPTOR MODULATORS

Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors. Methods of treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors of Formula (I).

Hepatitis C Virus Inhibitors

Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

HEPATITIS C VIRUS INHIBITORS

Hepatitis C virus inhibitors are disclosed having the general formula:(I) wherein R1, R2, R3, R', B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds toinhibit HCV are also disclosed.

Synthesis of 3,4-dihydro-1(2H)-isoquinolinones

Approaches toward the preparative-scale synthesis of target 3,4-dihydro-1(2H)-isoquinolinones 1-3 are presented. Compounds 1 and 2 were prepared via a Schmidt rearrangement on easily obtained indanone precursors, but in low overall yield. A better method

5-Nitrofuran-2-ylmethyl group as a potential bioreductively activated pro-drug system

5-Substituted isoquinolin-1-ones have been synthesised by one-pot Curtius rearrangement of the corresponding substituted 3-phenylpropenoyl azides and cyclisation. Arylmethylation of the anions of the isoquinolinones with benzyl halides [4-methoxybenzyl chloride, 2-(chloromethyl)furan and 5-nitro-2-(tosyloxymethyl)furan] takes place exclusively at nitrogen. Nitration of 2-(furan-2-ylmethyl)isoquinolin-1-one in strongly acidic medium gives 2-(5-nitrofuran-2-ylmethyl)isoquinolin-1-one, whereas weaker acidic conditions lead to dinitration. Curtius rearrangement of 3-carboranylbutanoyl azide and trapping with 5-nitrofuran-2-ylmethanol gives 5-nitrofuran-2-ylmethyl N-(3-carboranylpropyl)carbamate. Biomimetic reduction of these nitrofuranylmethyl derivatives of anticancer drugs triggers release of the parent drugs. Thus, these nitrofurans have potential applications as pro-drugs for selective release of therapeutic drugs in hypoxic solid tumours.

Folate analogues. 35. synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogues of n10-propargyl-5, 8-dideazafolic acid1

Structural modifications at the pyrimidine ring and at the C9,N10-bridge region of the thymidylate synthase (TS) inhibitors N10-propargyl-5,8-dideazafolate (1; PDDF; CB 3717), 2-desamino-N10-propargyl-5,8-dideaz

Palladium-catalyzed Synthesis of Isocoumarin and 1-Isoquinolinone Derivatives

In the presence of copper(I) chloride, the palladium catalyzed oxidation of methyl 2-ethenylbenzoates and 2-ethenylbenzamides have been studied.This reaction was used to form isocoumarins and 1-isoquinolinones.