2419-74-1

Basic information

• Product Name: 1,4-DICHLORO-2-BUTANOL
• Synonyms: dichlorobutanol;1,4-DICHLORO-2-BUTANOL;DI CHLORIDE NORMAL BUTANOL;1,4-dichlorobutan-2-ol;1,4-DICHLORO-2-BUTANOL 95+%
• CAS NO: 2419-74-1
• Molecular Formula: C₄H₈Cl₂O
• Molecular Weight: 143.01
• EINECS: 219-339-2
• Mol File: 2419-74-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 227.7 °C at 760 mmHg
• Flash Point: 103.7 °C
• Appearance: /
• Density: 1,29 g/cm3
• Vapor Pressure: 0.0149mmHg at 25°C
• Refractive Index: 1.4800 to 1.4830
• PKA: 13.58±0.20(Predicted)
• CAS DataBase Reference: 1,4-DICHLORO-2-BUTANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-DICHLORO-2-BUTANOL(2419-74-1)
• EPA Substance Registry System: 1,4-DICHLORO-2-BUTANOL(2419-74-1)

Safety Data

• Hazardous Substances Data: 2419-74-1(Hazardous Substances Data)

Usage

General Description

1,4-Dichloro-2-butanol is a chemical compound with the formula C4H8Cl2O. It is a colorless liquid with a chlorine-like odor, and it is primarily used as an intermediate in the production of other chemicals. 1,4-Dichloro-2-butanol is also known for its use in the synthesis of pharmaceuticals and agrochemicals. It is toxic to the liver and kidneys, and prolonged exposure to this compound can cause irritation to the skin, eyes, and respiratory system. Additionally, it is classified as a possible human carcinogen. The compound also has moderate water solubility and low volatility, making it less likely to be present in the air, and more likely to accumulate in soil and water.

InChI:InChI=1/C4H8Cl2O/c5-2-1-4(7)3-6/h4,7H,1-3H2

Upstream product

• 78-93-3 butanone 
• 16714-78-6 1,4-dichloro-2-butanone 
• 3068-00-6 D,L-1,2,4-butanetriol 
• 453-20-3 3-Hydroxytetrahydrofuran 

Downstream Products

• 59748-01-5 4-chloro-1-(2-methoxyphenoxy)-2-butanol 
• 59747-94-3 4-chloro-1-(3,5-dimethylphenoxy)-2-butanol 
• 59747-92-1 4-chloro-1-phenoxy-2-butanol 
• 116290-66-5 4-chloro-1-(4-nitrophenoxy)-2-butanol 
• 13220-33-2 1-methyl-3-pyrrolidinol 
• 42729-56-6 N-isopropyl-3-hydroxypyrrolidine 
• 30727-14-1 N-ethyl-3-hydroxypyrrolidine 
• 775-15-5 1-benzyl-3-pyrrolidinol 
• 34680-20-1 α-[3-chloro-4-(3-hydroxypyrrolidino)-phenyl]-propionic acid 
• 116290-68-7 4-(4-Chloro-2-hydroxybutoxy)benzonitrile 
• 116290-64-3 1-(4-bromophenoxy)-4-chloro-2-butanol 
• 116290-65-4 4-chloro-1-(4-methylphenoxy)-2-butanol 
• 59748-11-7 4-Chloro-1-(4-acetylphenoxy)-2-butanol 
• 59748-05-9 4-chloro-1-(4-methoxyphenoxy)-2-butanol 

Relevant articles and documents

Preparation method of N-substituent-3-hydroxytetrahydropyrrole

The invention discloses a preparation method of N-substituent-3-hydroxytetrahydropyrrole. The preparation method takes 1,2,4-butanetriol as a starting material, and comprises the following steps: performing a halogenating reaction between the starting material and hydrogen halide to prepare an intermediate 1,4-dihalogeno-2-butanol first, and then performing a condensation reaction with primary amine RNH2 to obtain a target product, wherein R represents methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tertiary butyl or benzyl; the halogenating reaction is performed in the presence of an acidic catalyst, and the acidic catalyst is formic acid or acetic acid; and hydrogen halide is hydrogen chloride or hydrogen bromide. The preparation method disclosed by the invention is relatively short in synthetic route, the starting material 1,2,4-butanetriol is low in price and easy to obtain, and other materials used in the method are relatively high in safety and also relatively low in price, so that the preparation method is suitable for industrial large-scale production. Particularly, the halogenating reaction can obtain a yield of 50% or above by selection of suitable halogenating agents and catalysts.

Lithium or Bromomagnesium 1,4- and 1,5-Dilithioalkan-2-yloxides: Preparation and Synthetic Applications

Treatment of chloromethyl 2- or 3-chloroalkyl carbinols with butyllithium and then lithium naphthalenide or with ethylmagnesium bromide and then powdered lithium leads to the formation of lithium or bromomagnesium dilithiothioalkoxides, respectively, which represent trianionic species.The bromomagnesium 1,ω-dilithio-2-alkoxides undergo immediate elimination of lithium bromide and magnesium oxide to give ω-lithio-1-alkenes.These latter organometallic compounds as well as the lithium dithioalkoxides react with various electrophiles to afford functionalized compounds.