24202-71-9Relevant academic research and scientific papers
Discovery of novel Syk/PDGFR-α/c-Kit inhibitors as multi-targeting drugs to treat rheumatoid arthritis
Li, Xiaokang,Huang, Yahui,Cheng, Junfei,Zhang, Lingling,Mao, Fei,Zhu, Jin,Sheng, Chunquan,Li, Jian
, p. 4375 - 4381 (2018)
Due to the complex biological pathways involved in rheumatoid arthritis, discovery of multi-targeting small molecules provides an effective strategy to achieve better efficacy and lower toxicity. Herein the first Syk/PDGFR-α/c-Kit inhibitors were designed and evaluated. Dihydrofuropyrimidine derivative 13 showed potent inhibitory activity against the three targets. Importantly, compound 13 exhibited good cellular efficacy against fibroblast-like synoviocytes (IC50 = 3.21 μM) and mouse bone marrow-derived mast cells (IC50 = 2.03 μM) and significantly decreased the secretion of inflammatory cytokines. Thus, Syk/PDGFR-α/c-Kit triple inhibitor 13 represented a promising lead compound for the treatment of RA.
1,5-DIHETEROCYCLE-1H-TRIAZOLE DERIVATIVE
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Page/Page column 29-30, (2010/11/27)
The present invention relates to a compound represented by Formula (I): wherein Ar1, Ar2, R1 and R2 each represent a substituent, a salt thereof, or a solvate of the compound or the salt, and to a medicine containing the same. According to the present invention, a potent platelet aggregation suppressant which does not inhibit COX-1 and COX-2 is provided.
FIVE-MEMBERED HETEROCYCLIC DERIVATIVE
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Page/Page column 60, (2010/11/08)
The present invention relates to a compound represented by formula (I): a salt of the compound, or a solvate of the compound or the salt; a drug containing any of the compounds, the salts, and the solvates; a preventive and/or therapeutic agent for an ischemic disease containing any of the compounds, the salts, and the solvates; and a platelet coagulation inhibitor containing any of the compounds, the salts, and the solvates. The compound of the present invention is useful as a strong platelet coagulation inhibitor without inhibiting COX-1 or COX-2.
Pyridine-2,4- and -2,5-dicarboxylic acid derivatives and medicaments based on these compounds
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, (2008/06/13)
The invention relates to pyridine-2,4- and -2,5-dicarboxylic acid derivatives of the formula I STR1 in which R1, R2 and X have the meanings given, a process for the preparation of these compounds and their use, in particular in medic
