24223-74-3

Upstream product

• 551-16-6 6-Aminopenicillanic Acid 
• 69399-79-7 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride 

Downstream Products

• 482585-90-0 [Fe(C₁₉H₁₆ClFN₃O₅S)(H₂NCH₂COO)]*H₂O 
• 482585-99-9 [Fe(C₁₉H₁₆ClFN₃O₅S)(H₂NCH(CH₃)COO)(Cl)(H₂O)] 
• 482585-98-8 [Fe(C₁₉H₁₆ClFN₃O₅S)(H₂NCH(CH₃)COO)]*H₂O 
• 482586-01-6 [Co(C₁₉H₁₆ClFN₃O₅S)(H₂NCH(CH₃)COO)(H₂O)2] 
• 482586-02-7 [Ni(C₁₉H₁₆ClFN₃O₅S)(H₂NCH(CH₃)COO)(H₂O)2] 
• 1847-24-1 Flucloxacillin sodium 
• 124-38-9 carbon dioxide 
• 142185-31-7 5,5-dimethyl-thiazolidine-2,4-dicarboxlic acid 
• 3919-74-2 3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid 
• 75524-31-1 5-Hydroxymethylflucloxacillin 

Relevant academic research and scientific papers

Flucloxacillin sodium monohydrate synthetic method

The invention discloses a method for compounding flucloxacillin sodium-hydrate, which belongs to the technical field of drug synthesis, and comprises the steps: 6-aminopenicillanic acid (6-APA) is salified, then 3-(2-chloro-6-fluorophenyl)-5- methyl isoxazole-4-formyl chloride or equivalents thereof are added to do an acylation reaction, and then acids are added drop by drop to adjust a potential of hydrogen (pH) value to obtain flucloxacillin acid aqueous solutions. Organic solution is used to extract, and organic phases are washed, dried and filtered to obtain flucloxacillin acid solutions through saturated salt water, then white solids are dissolved out in the flucloxacillin acid solutions which are added with sodium iso-octoate solutions, and products are obtained by controlling temperature and crystallizing. The method for compounding the flucloxacillin sodium-hydrate does not separate intermediate flucloxacillin acids, obtained flucloxacillin acids are directly salified with sodium iso-octoate after being extracted trough the organic solution, reduces separation steps and operation process, also reduces usage amount and times of organic solution simultaneously, greatly reduces discharge amount of organic solution relative to patent documentation CN 102964356A, reduces production cost above 20%, and obviously improves economic and environmental values.