24228-13-5

Usage

Uses

Used in Organic Synthesis:
2-Hydroxy-3-phenylpyridine is used as an intermediate in the synthesis of complex chemical compounds, contributing to the formation of a wide range of organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Hydroxy-3-phenylpyridine is used as an intermediate for the production of various drugs, playing a crucial role in the development of new medications.
Used in Inorganic and Organometallic Chemistry:
2-Hydroxy-3-phenylpyridine is used as a ligand in inorganic and organometallic chemistry, facilitating the formation of coordination complexes with central metal atoms, which are essential in various chemical reactions and applications.

InChI:InChI=1/C11H9NO/c13-11-10(7-4-8-12-11)9-5-2-1-3-6-9/h1-8H,(H,12,13)

Upstream product

• 536-74-3 phenylacetylene 
• 13466-43-8 3-bromopyridin-2(1H)-one 
• 98-80-6 phenylboronic acid 
• 142-08-5 2-Pyridone 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 20265-38-7 3-amino-2-methoxypyridine 
• 53698-45-6 2-methoxy-3-phenylpyridine 
• 1008-88-4 3-phenylpyridine 
• 557-01-7 Pyrimidin-2(1H)-one 
• 125641-55-6 1-tert-Butyl-3-phenyl-1H-pyridin-2-one 

Downstream Products

• 104813-87-8 1-(3-phenyl-2-pyridinyl)piperazine 
• 104813-67-4 4,4-dimethyl-1-[4-[4-(3-phenyl-2-pyridinyl)-1-piperazinyl]butyl]-2,6-piperidinedione 
• 104813-61-8 3-{4-[4-(3-Phenyl-pyridin-2-yl)-piperazin-1-yl]-butyl}-1-thia-3-aza-spiro[4.4]nonane-2,4-dione 
• 104813-63-0 4-{4-[4-(3-Phenyl-pyridin-2-yl)-piperazin-1-yl]-butyl}-morpholine-3,5-dione 
• 143075-08-5 1,2-dihydro-1-<<5(4)-methyl-4(5)-imidazolyl>methyl>-2-oxo-3-phenylpyridine 
• 51551-56-5 (RS)-3-phenylpiperidin-2-one 

Relevant academic research and scientific papers

Propionic Acid Derivatives and Methods of Use Thereof

Provided herein are compounds and pharmaceutical compositions of formula I where R1, R2, R3, R4, R5 and R6 are as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.

A nitrogen oxide C2 - bit hydroxylated method (by machine translation)

The present invention relates to nitrogen oxide C2 - bit hydroxylated method, in particular under reflux conditions in dichloroethane, three pyrrole alkyl bromide (PyBrop) [...] phosphate, sodium acetate, water and nitrogen oxides produced by the reaction of hydroxyl-substituted product. The process has simple operation, mild condition, high reaction selectivity, substrate wide applicability, high yield and the like. The application for the first time using this method to synthesize a series of 2 - hydroxyquinoline, 2 - hydroxy pyridine and 1 - hydroxy isoquinoline compound, in the establishment of the compounds of the library synthesis application have broad prospects. (by machine translation)

Highly c3-selective direct alkylation and arylation of 2-pyridones under visible-light-promoted photoredox catalysis

An Ir photoredox catalyst-mediated highly site-selective direct alkylation and arylation of 2-pyridones has been developed. Under visible-light-promoted conditions, ethyl 2-bromo-2,2-difluoroacetate couples with various 2-pyridones exclusively at the C3 position. A similar photoredox catalysis is also effective for the direct C3- Arylation with diaryliodonium triflates. Thus, these reactions occurs under very mild conditions (blue LEDs irradiation and ambient temperature) to form the corresponding C3- Alkylated and arylated 2-pyridones of potential interest in medicinal and pharmaceutical chemistry.

Pyridonate-Supported Titanium(III). Benzylamine as an Easy-To-Use Reductant

The reaction of bis(3-phenyl-2-pyridonate)Ti(NMe2)2 with excess benzylamine leads to an unexpected reduction of the metal center from Ti(IV) to Ti(III). The reduced titanium species was isolated and revealed as tris(3-phenyl-2-pyrido

2-Pyridonate titanium complexes for chemoselectivity. accessing intramolecular hydroaminoalkylation over hydroamination

Chemoselectivity of intramolecular hydroaminoalkylation over hydroamination has been achieved with a bis(3-phenyl-2-pyridonate) titanium complex. Primary aminoalkenes are selectively α-alkylated by C-H functionalization adjacent to nitrogen to access five

Caspase inhibitors and uses thereof

This invention provides novel compounds, and pharmaceutically acceptable derivatives thereof, that are useful as caspase inhibitors. These compounds have the general formula I: where R1, R2, and R3 are as described herein, Ring A contains zero to two double bonds, each X is independently selected from nitrogen or carbon, at least one X in Ring A is a nitrogen, Ring A is optionally substituted as described, and may be fused to a saturated or unsaturated five to seven membered ring containing zero to three heteroatoms, and provided that when X3 is a carbon, a substituent on X3 is attached by an atom other than nitrogen.

Synthesis and Biological activity of kappa opioid receptor agonists. Part 2: Preparation of 3-aryl-2-pyridone analogues generated by solution- and solid-phase parallel synthesis methods

New analogues of the previously described 3-aryl pyridone KOR agonists have been synthesised by parallel synthetic methods, both in solution- and with solid-phase chemistry, making use of the well known and versatile Mitsunobu, Suzuki and Buchwald reactions. Opioid receptor binding data for the compounds produced is reported.

3-Aryl pyridone derivatives. Potent and selective kappa opioid receptor agonists

A new series of 3-aryl pyridone based kappa opioid receptor agonists was designed and synthesised, based on an understanding of the classical kappa opioid receptor pharmacophore. The most potent of the new compounds were comparable to U-69,593 in receptor affinity, selectivity and functional agonist effect at the cloned human kappa opioid receptor.

ANTIPSYCHOTIC CYCLIC IMIDE DERIVATIVES OF 2-(4-BUTYLPIPERAZIN-1-YL) PYRIDINES, COMPOSITIONS AND USE

Disubstituted N,N-piperazinyl derivatives are disclosed wherein one substituent is a substituted pyridin-2-yl ring and the second substituent is a butylene chain attached to cyclic imide heterocycles such as azaspiro 4.5!decanedione, dialkylglutarimide, thiazolidinedione, spirocyclopentylthiazolidinedione, or morpholine-2,6-dione. The compounds have psychotropic properties and 2-4-4-(2,4-dioxo-1-thia-3-azaspiro 4. 5!nonane-3-yl)butyl!-1-piperazinyl!-pyridine-3-carboxaldehyde is a typical embodiment having selective antipsychotic activity.