24228-13-5

Basic information

• Product Name: 2-HYDROXY-3-PHENYLPYRIDINE
• Synonyms: 2-HYDROXY-3-PHENYLPYRIDINE;3-PHENYL-2-HYDROXYPYRIDINE;3-Phenylpyridin-2-ol
• CAS NO: 24228-13-5
• Molecular Formula: C₁₁H₉NO
• Molecular Weight: 171.2
• Mol File: 24228-13-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 225-227 °C
• Boiling Point: 417.1 °C at 760 mmHg
• Flash Point: 246.1 °C
• Appearance: /
• Density: 1.158 g/cm³
• Vapor Pressure: 3.64E-07mmHg at 25°C
• Refractive Index: 1.594
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.80±0.10(Predicted)
• CAS DataBase Reference: 2-HYDROXY-3-PHENYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-3-PHENYLPYRIDINE(24228-13-5)
• EPA Substance Registry System: 2-HYDROXY-3-PHENYLPYRIDINE(24228-13-5)

Safety Data

• Hazardous Substances Data: 24228-13-5(Hazardous Substances Data)

Usage

General Description

2-Hydroxy-3-phenylpyridine is a chemical compound made up of carbon, hydrogen, nitrogen and oxygen atoms. It is characterized by a pyridine ring, a class of organic compounds characterized by a six-membered ring containing one nitrogen atom, substituted with a hydroxy group (-OH) and a phenyl ring. 2-HYDROXY-3-PHENYLPYRIDINE is broadly used in the field of organic synthesis and pharmaceuticals, often acting as an intermediate in the production of more complex chemical compounds or drugs. It is recognized for its ability to serve as a ligand, a molecule that binds to a central metal atom to form a coordination complex, in various inorganic and organometallic reactions. It is advisable to handle this chemical with care as it may present health hazards if improperly managed.

InChI:InChI=1/C11H9NO/c13-11-10(7-4-8-12-11)9-5-2-1-3-6-9/h1-8H,(H,12,13)

Upstream product

• 5470-18-8 2-Chloro-3-nitropyridine 
• 20265-38-7 3-amino-2-methoxypyridine 
• 53698-45-6 2-methoxy-3-phenylpyridine 
• 142-08-5 2-Pyridone 
• 13466-43-8 3-bromopyridin-2(1H)-one 
• 98-80-6 phenylboronic acid 
• 557-01-7 Pyrimidin-2(1H)-one 
• 536-74-3 phenylacetylene 
• 1008-88-4 3-phenylpyridine 
• 125641-55-6 1-tert-Butyl-3-phenyl-1H-pyridin-2-one 

Downstream Products

• 51551-56-5 (RS)-3-phenylpiperidin-2-one 
• 143075-08-5 1,2-dihydro-1-<<5(4)-methyl-4(5)-imidazolyl>methyl>-2-oxo-3-phenylpyridine 
• 104813-63-0 4-{4-[4-(3-Phenyl-pyridin-2-yl)-piperazin-1-yl]-butyl}-morpholine-3,5-dione 
• 104813-61-8 3-{4-[4-(3-Phenyl-pyridin-2-yl)-piperazin-1-yl]-butyl}-1-thia-3-aza-spiro[4.4]nonane-2,4-dione 
• 104813-67-4 4,4-dimethyl-1-[4-[4-(3-phenyl-2-pyridinyl)-1-piperazinyl]butyl]-2,6-piperidinedione 
• 104813-87-8 1-(3-phenyl-2-pyridinyl)piperazine 

Relevant articles and documents

Propionic Acid Derivatives and Methods of Use Thereof

Provided herein are compounds and pharmaceutical compositions of formula I where R1, R2, R3, R4, R5 and R6 are as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.

Highly c3-selective direct alkylation and arylation of 2-pyridones under visible-light-promoted photoredox catalysis

An Ir photoredox catalyst-mediated highly site-selective direct alkylation and arylation of 2-pyridones has been developed. Under visible-light-promoted conditions, ethyl 2-bromo-2,2-difluoroacetate couples with various 2-pyridones exclusively at the C3 position. A similar photoredox catalysis is also effective for the direct C3- Arylation with diaryliodonium triflates. Thus, these reactions occurs under very mild conditions (blue LEDs irradiation and ambient temperature) to form the corresponding C3- Alkylated and arylated 2-pyridones of potential interest in medicinal and pharmaceutical chemistry.

2-Pyridonate titanium complexes for chemoselectivity. accessing intramolecular hydroaminoalkylation over hydroamination

Chemoselectivity of intramolecular hydroaminoalkylation over hydroamination has been achieved with a bis(3-phenyl-2-pyridonate) titanium complex. Primary aminoalkenes are selectively α-alkylated by C-H functionalization adjacent to nitrogen to access five