53698-45-6

Basic information

• Product Name: Pyridine, 2-methoxy-3-phenyl-
• CAS NO: 53698-45-6
• Molecular Formula: C12H11NO
• Molecular Weight: 185.225
• Mol File: 53698-45-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Pyridine, 2-methoxy-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-methoxy-3-phenyl-(53698-45-6)
• EPA Substance Registry System: Pyridine, 2-methoxy-3-phenyl-(53698-45-6)

Safety Data

• Hazardous Substances Data: 53698-45-6(Hazardous Substances Data)

Usage

General Description

2-methoxy-3-phenylpyridine, also known as 2-methoxy-3-phenyl pyridine, is a chemical compound with the molecular formula C12H11NO. It is a derivative of pyridine and is commonly used in the synthesis of pharmaceuticals and agrochemicals. 2-methoxy-3-phenylpyridine has a pale yellow to brown color and a strong odor. It is considered to be both an irritant and potentially harmful if ingested or inhaled. The compound is also used as a building block for the production of various organic compounds and has potential applications in medicinal chemistry.

Upstream product

• 31557-57-0 2-chloro-3-phenyl-pyridine 
• 124-41-4 sodium methylate 
• 1628-89-3 2-methoxypyridine 
• 108-90-7 chlorobenzene 
• 16498-81-0 2-methoxynicotinic acid 
• 71-43-2 benzene 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 20265-38-7 3-amino-2-methoxypyridine 
• 98-80-6 phenylboronic acid 
• 112197-15-6 3-iodo-2-methoxypyridine 
• 20265-35-4 2-methoxy-3-nitropyridine 

Downstream Products

• 24228-13-5 2-hydroxy-3-phenylpyridine 

Relevant articles and documents

Decarboxylative Suzuki-Miyaura coupling of (hetero)aromatic carboxylic acids using iodine as the terminal oxidant

A novel methodology for the decarboxylative Suzuki-Miyaura-type coupling has been established. This process uses iodine or a bromine source as both the decarboxylation mediator and the terminal oxidant, thus avoiding the need for stoichiometric amounts of transition metal salts previously required. Our new protocol allows for the construction of valuable biaryl architectures through the coupling of (hetero)aromatic carboxylic acids with arylboronic acids. The scope of this decarboxylative Suzuki reaction has been greatly diversified, allowing for previously inaccessible non-ortho-substituted aromatic acids to undergo this transformation. The procedure also benefits from low catalyst loadings and the absence of stoichiometric transition metal additives.

METHOD FOR PRODUCING AROMATIC COMPOUND

In a cross coupling reaction, in a case where a halogen atom is selected as the leaving group of the raw material compound, a harmful halogen waste forms as a by-product after the reaction, and disposal of the waste liquid is complicated and environmental burden is high. In a carbon-hydrogen activation cross coupling reaction which requires no halogen atom as the leaving group, although no halogen waste forms as a by-product, the reaction substrate is considerably restricted, and the reaction remains a limited molecular construction method. A method for producing an aromatic compound, which comprises subjecting an aromatic nitro compound and a boronic acid compound to a cross coupling reaction in the presence of a metal catalyst.

The Suzuki-Miyaura Coupling of Nitroarenes

Synthesis of biaryls via the Suzuki-Miyaura coupling (SMC) reaction using nitroarenes as an electrophilic coupling partners is described. Mechanistic studies have revealed that the catalytic cycle of this reaction is initiated by the cleavage of the aryl-nitro (Ar-NO2) bond by palladium, which represents an unprecedented elemental reaction.