24239-18-7

Usage

Molecular Structure

The compound consists of a benzothiazole ring with a 4-bromomethyl-phenyl substituent.

Usage

It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals.

Potential Applications

2-(4-Bromomethyl-phenyl)-benzothiazole has potential applications in the development of novel drugs due to its pharmacological properties.

Utilization in Organic Synthesis

It is utilized in organic synthesis as a building block for the creation of more complex molecules.

Material Science Applications

It has been studied for its potential use in materials science.

Fluorescent Probe

2-(4-Bromomethyl-phenyl)-benzothiazole has been studied as a fluorescent probe for biological imaging.

Diverse Applications

This chemical compound has diverse applications and is of interest in various fields of research and industry.

Upstream product

• 16112-21-3 2-(4-methylphenyl)-1,3-benzothiazole 
• 137-07-5 2-amino-benzenethiol 
• 99-94-5 p-Toluic acid 
• 104-82-5 4-Methylbenzyl chloride 
• 104-87-0 4-methyl-benzaldehyde 
• 874-60-2 4-methyl-benzoyl chloride 
• 56108-06-6 p-toluimidic acid methyl ester 

Downstream Products

• 36078-38-3 2-(4-morpholin-4-ylmethyl-phenyl)-benzothiazole 
• 36078-39-4 2-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-benzothiazole 
• 36078-27-0 (4-benzothiazol-2-yl-benzyl)-propyl-amine 
• 36078-26-9 (4-benzothiazol-2-yl-benzyl)-ethyl-amine 
• 36078-31-6 2-(4-benzothiazol-2-yl-benzylamino)-ethanol 
• 36078-28-1 (4-benzothiazol-2-yl-benzyl)-isopropyl-amine 
• 34211-03-5 (4-benzothiazol-2-yl-benzyl)-tert-butyl-amine 
• 36078-35-0 (4-benzothiazol-2-yl-benzyl)-diisopropyl-amine 
• 36078-36-1 2,2'-(4-benzothiazol-2-yl-benzylazanediyl)-bis-ethanol 
• 75889-63-3 1-(benzothiazol-2-yl)-4-di-n-propyloxyphosphinylmethylbenzene 
• 75925-95-0 4-(Benzothiazol-2-yl)benzylphosphonic Acid 1,3-Propanediol Cyclic Ester 
• 128766-87-0 (4-Benzothiazol-2-yl-benzyl)-phosphonic acid 3-bromo-propyl ester ethyl ester 
• 75889-64-4 1-(benzothiazol-2-yl)-4-di-iso-propyloxyphosphinylmethylbenzene 
• 75889-65-5 1-(benzothiazol-2-yl)-4-di-n-butyloxyphosphinylmethylbenzene 

Relevant academic research and scientific papers

Benzothiazole derivatives containing different electron acceptors exhibiting totally different data-storage performances

Two small conjugated molecules BTVCz-NO2 and BTVCz, each incorporating an electron-donating carbazole group and a medium electron-withdrawing benzothiazole group, were both successfully designed and synthesized. Molecule BTVCz-NO2 is

Small-compound enhancers for functional O-mannosylation of alpha-dystroglycan, and uses thereof

The present invention provides compounds that can enhance functional O-mannosylation of proteins including alpha-dystroglycan. Also provided are methods of preparation of the compounds defined by the formula I. Also provided are the methods of using the compounds or the pharmaceutical acceptable salts or prodrugs thereof in treating and preventing subjects suffering from the diseases including muscular dystrophies and cancers.

Influence of the methylene group between azadithiolate nitrogen atom and phenyl moiety on the protophilic properties of [FeFe]-hydrogenase model complexes

An [FeFe]-hydrogenase mimic 4 with functional benzyl moiety covalently linked to the azadithiolate ligand was synthesized. The structure, protonation, and electrochemical properties of 4 and a phenyl substituted analogue (coded as 3) were simultaneously s

An artificial [FeFe]-hydrogenase mimic with organic chromophore-linked thiolate bridges for the photochemical production of hydrogen

An artificial [FeFe]-hydrogenase ([FeFe]-H2ase) mimic 3II, consisting of dual organic chromophores covalently assembled to the [Fe2S2] active site, was constructed for light-driven hydrogen evolution. The structural confor

Specific self-monitoring of metal-associated amyloid-β peptide disaggregation by a fluorescent chelator

A dual-functional fluorescent chelator can specifically target and disassemble metal-associated Aβ aggregates and simultaneously self-monitor the disaggregation by fluorescence in brain homogenates of mice with Alzheimer's disease.

Small molecules enhance functional O-mannosylation of Alpha-dystroglycan

Alpha-dystroglycan (α-DG), a highly glycosylated receptor for extracellular matrix proteins, plays a critical role in many biological processes. Hypoglycosylation of α-DG results in various types of muscular dystrophies and is also highly associated with progression of majority of cancers. Currently, there are no effective treatments for those devastating diseases. Enhancing functional O-mannosyl glycans (FOG) of α-DG on the cell surfaces is a potential approach to address this unmet challenge. Based on the hypothesis that the cells can up-regulate FOG of α-DG in response to certain chemical stimuli, we developed a cell-based high-throughput screening (HTS) platform for searching chemical enhancers of FOG of α-DG from a large chemical library with 364,168 compounds. Sequential validation of the hits from a primary screening campaign and chemical works led to identification of a cluster of compounds that positively modulate FOG of α-DG on various cell surfaces including patient-derived myoblasts. These compounds enhance FOG of α-DG by almost ten folds, which provide us powerful tools for O-mannosylation studies and potential starting points for the development of drug to treat dystroglycanopathy.

Glycosylated star-shaped conjugated oligomers for targeted two-photon fluorescence imaging

A glucopyranose functionalized star-shaped oligomer, N-tris{4,4',4"- [(1E)-2-(2-{(E)-2-[4-(benzo[d]thiazol-2-yl)phenyl]vinyl}-9,9-bis(6-2-amido-2- deoxy-1-thio-β-D-glucopyranose-hexyl)-9H-fluoren-7-yl)vinyl]phenyl} phenylamine (TVFVBN-S-NH2), i

Synthesis, photophysical and electrochemical properties and theoretical studies on three novel indolo[3,2-b]carbazole derivatives containing benzothiazole units

Three novel indolo[3,2-b]carbazoles derivatives were successfully synthesized by condensation reaction and structurally characterized by elemental analysis, mass spectrometry and proton nuclear magnetic resonance spectroscopy methods, which belong to dono

Experimental and theoretical study of three new benzothiazole-fused carbazole derivatives

Three new D-π-A type compounds, each containing one benzothiazole ring as an electron acceptor and one N-ethylcarbazole group as electron donor, were synthesized and characterized by elemental analysis, NMR, MS and thermogravimetric analysis. The absorption and emission spectra of three compounds were experimentally determined in several solvents and were simultaneously computed using density functional theory (DFT) and time-dependent density functional theory (TDDFT). The calculated reorganization energy for hole and electron indicates that three compounds are in favor of hole transport than electron transport. The calculated absorption and emission wavelengths are well coincident with the measured data. The calculated lowest-lying absorption spectra can be mainly attributed to intramolecular charge transfer (ICT). And the calculated fluorescence spectra can be mainly described as originating from an excited state with intramolecular charge transfer (ICT) character. The results show that three compounds exhibited excellent thermal stability and high fluorescence quantum yields, indicating their potential applications as excellent optoelectronic material in optical field.

Synthesis and DSSC application of novel dendrimers with benzothiazole and triazole units

Synthesis of novel dendrimers with benzothiazole as surface group and triazole as branching unit is achieved through click chemistry. The presence of more number of benzothiazole and triazole units increases the molar absorption coefficient and alters the