16112-21-3

Usage

Uses

Used in Pharmaceutical Research:
2-(4-METHYLPHENYL)-BENZOTHIAZOLE is used as a chemical intermediate in the synthesis of various pharmaceutical compounds due to its unique structure and potential pharmacological properties.
Used in Antimicrobial Applications:
2-(4-METHYLPHENYL)-BENZOTHIAZOLE is used as an antimicrobial agent for its ability to inhibit the growth of certain bacteria, making it a potential candidate for use in medical and healthcare applications.
Used in Antifungal Applications:
2-(4-METHYLPHENYL)-BENZOTHIAZOLE is used as an antifungal agent for its potential to inhibit the growth of fungi, which can be beneficial in treating fungal infections and in agricultural applications.
Used in the Textile Industry:
2-(4-METHYLPHENYL)-BENZOTHIAZOLE is used as an optical brightening agent in the textile industry to enhance the appearance of fabrics by reflecting more light, giving them a brighter and more vibrant look.
Used in Organic Synthesis:
2-(4-METHYLPHENYL)-BENZOTHIAZOLE is used as a building block in the synthesis of various organic compounds, including other benzothiazole derivatives with potential applications in various fields.

InChI:InChI=1/C14H11NS/c1-10-6-8-11(9-7-10)14-15-12-4-2-3-5-13(12)16-14/h2-9H,1H3

Upstream product

• 106-43-4 para-chlorotoluene 
• 137-07-5 2-amino-benzenethiol 
• 99-94-5 p-Toluic acid 
• 57774-66-0 N-(Ethoxycarbonyl)-4-methylbenzenethiocarboxamide 
• 67213-27-8 p-methylselenobenzamide 
• 615-43-0 2-iodophenylamine 
• 90016-92-5 Copper(I); 4-methyl-benzenecarbothioate 
• 14111-33-2 diethyl 2-(4-methylbenzylidene)malonate 
• 104-87-0 4-methyl-benzaldehyde 
• 6140-17-6 4-methylbenzotrifluoride 
• 1155-00-6 bis(2-nitrophenyl)disulfide 
• 104-85-8 para-methylbenzonitrile 
• 615-22-5 2-methylmercaptobenzothiazole 
• 31614-66-1 tributyl(p-tolyl)stannane 

Downstream Products

• 132631-53-9 4-(2-benzothiazolyl) phenylmethane thiol 
• 132631-58-4 2-(4-ethoxymethyl phenyl) benzothiazole 
• 132631-56-2 2-(4-ethylthiomethyl phenyl) benzothiazole 
• 132631-54-0 4-(2-benzothiazolyl) phenylmethane sulfonic acid 
• 132631-57-3 ethyl 4-(2-benzothiazolyl) benzyl sulfone 
• 132631-52-8 4-benzyl (2-benzothiazolyl) ethylxanthogenate 
• 132631-55-1 4-(2-benzothiazolyl) phenylmethane methylsulfonate 
• 132631-61-9 sodium 4-benzothiazolyl phenylmethane sulfonate 
• 1338053-24-9 2-(4-(azidomethyl)phenyl)benzothiazole 
• 24239-18-7 2-<4-(bromomethyl)phenyl>benzothiazole 
• 2548-64-3 2-(4-(benzothiazol-2-yl)phenyl)acetonitrile 
• 101078-64-2 diethyl 4-(6-aminobenzothiazol-2-yl)benzylphosphonate hydrochloride 
• 101078-65-3 diethyl 4-<6-(acetylamino)benzothiazol-2-yl>benzylphosphonate 
• 101078-63-1 diethyl 4-(6-nitrobenzothiazol-2-yl)benzylphosphonate 

Relevant academic research and scientific papers

Synthesis of 2-aryl and coumarin substituted benzothiazole derivatives

A facile and effective method for the synthesis of some benzothiazole derivatives is described. The method involves the action of aryl aldehyde and o-aminothiophenol in acetic acid resulting into in situ formation of the thiol substituted Schiffs base and

Synthesis, characterization and crystal structure of Iridium(III)bis(2-p- tolyl-benzothiazolato-N,C2)(acetylacetonate)

A novel thiazole-based iridium (III) complex (iridium(III)bis(2-p-tolyl- benzothiazolato-N,C2)(acetylacetonate)) has been prepared and fully characterized by EA, IR, 1H-NMR and MS. The molecular structure of the complex has been dete

Mono- and binuclear palladacycles via regioselective C-H bond activation: Syntheses, mechanistic insights and catalytic activity in direct arylation of azoles

Regioselective C-H bond palladation of the hybrid pincer-type ligands, 3-R2PO-C6H4-1-CH2NiPr2 [R2POCNiPr2-H; R = Ph (1a), R = Et2N (1b)] has been described

Ruthenium silicate (RS-1) zeolite: novel heterogeneous efficient catalyst for synthesis of 2-arylbenzothiazole derivatives

Abstract: Mesoporous silicate and transition metal (Ru+3) containing mesoporous silicate materials or ruthenium silicate Ru+3/Si+4 where synthesis by using hydrothermal process. Mesoporous ruthenium silicate (RS-1) and zeo

A simple synthesis of 2-arylbenzothiazoles and its application to palladium-catalyzed Mizoroki-Heck reaction

A variety of 2-arylbenzothiazoles were prepared by the direct reaction of 2-aminobenzenethiol and aryl aldehydes by the aid of activated carbon (Shirasagi KL or Darco KB) under oxygen atmosphere. 2-Pyridylbenzothiazole, thus obtained, was proved to work as an efficient ligand in palladium-catalyzed Mizoroki-Heck reaction.

Nano-Titania-Supported Sulfonic-Acid-Catalyzed Synthesis of 2-Arylbenzothiazole Derivatives under Solvent Free Conditions

Nano-titania-supported sulfonic acid (n-TSA) has been used as an efficient, inexpensive and reusable heterogeneous nano catalyst for synthesis of 2-arylbenzothiazole derivatives under solvent free condition. The reaction works very well, with good to exce

Microwave-assisted synthesis of benzothiazole derivatives using glycerol as green solvent

A rapid method has been developed for the synthesis of benzothiazoles via the condensation of 2-aminothiophenol with aldehydes under CEM-focused microwave irradiation conditions. The reaction used glycerol as a green solvent without any catalyst, renderin

Synthesis of fostedil (diethyl 4-(2-benzothiazolyl)benzylphosphonate) from N-acylimidates

Fostedil (diethyl 4-(benzothiazol-2-yl) benzylphosphonate) 7 has been synthesized efficiently by treatment of 2-(4-bromomethylphenyl) benzothiazole 6 with triethylphosphite. The latter (6) has been prepared by bromation of benzothiazole 3c. N-acylimidates 1(a-d) react with 2-aminobenzenethiol 2 to lead to the corresponding benzothiazoles 3(a-d) after elimination of primary amide 5. The structure of these products have been unequivocally confirmed by means of IR, 1H, 13C, and 31P NMR spectroscopy and mass spectra.

Direct C—H Bond Activation of Benzoxazole and Benzothiazole with Aryl Bromides Catalyzed by Palladium(II)-N-heterocyclic Carbene Complexes

Herein, we report that a series of novel palladium(II)-NHC complexes (NHC=N-heterocyclic carbene) were synthesized. The structures of all novel complexes were characterized by 1H NMR, 13C NMR, FT-IR spectroscopy and elemental analysis techniques. These palladium(II)-NHC complexes were tested as efficient catalysts in the direct C—H bond activation of benzoxazole and benzothiazole with aryl bromides in the presence of 1 mol% catalyst loading at 150 °C for 4 h. Under the given conditions, various aryl bromides were successfully applied as the arylating reagents to achieve the 2-arylbenzoxazoles and 2-arylbenzothiazoles in acceptable to high yields.

Yttrium-catalyzed heterocyclic formation via aerobic oxygenation: A green approach to benzothiazoles

The YCl3-catalyzed aerobic oxidative cyclization reaction for the synthesis of benzothiazoles has been developed. This method provides a practical, effective and green synthetic approach to benzothiazoles which are important units in many biologically active compounds.