2424-90-0

Usage

Uses

Used in Chemical Industry:
Heptadecanedioic acid is used as a precursor in the synthesis of various organic compounds, leveraging its long-chain structure for creating a diverse range of chemical products.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, Heptadecanedioic acid serves as a building block for the development of new drugs, potentially contributing to treatments and therapies through its chemical properties.
Used in Production of Biodegradable Polymers:
Heptadecanedioic acid is utilized as a component in the creation of biodegradable polymers, offering an environmentally friendly alternative to traditional plastics and contributing to a more sustainable industry.
Used in Cosmetics and Skincare Products:
Heptadecanedioic acid is employed as a moisturizing and emollient agent in cosmetics and skincare products, providing hydration and improving the texture of the skin due to its fatty acid nature.

InChI:InChI=1/C17H32O4/c18-16(19)14-12-10-8-6-4-2-1-3-5-7-9-11-13-15-17(20)21/h1-15H2,(H,18,19)(H,20,21)

Upstream product

• 31772-05-1 1,13-dibromotridecane 
• 996-82-7 sodium diethylmalonate 
• 1502-36-9 9-oxo-heptadecanedioic acid 
• 544-78-5 cycloheptadecene 
• 6568-55-4 cycloheptadecyne 
• 546-67-8 lead(IV) tetraacetate 
• 64-19-7 acetic acid 
• 4429-77-0 cycloheptadecanol 
• 1071-71-2 ethyl 6-chloro-6-oxohexanoate 
• 25077-25-2 N-methyladipinimide 
• 151276-57-2 methyl 16-cyanohexadecanoate 
• 110544-76-8 16-methanesulfonyloxy-hexadecanoic acid methyl ester 
• 36575-67-4 16-hydroxyhexadecanoic acid methyl ester 
• 100048-89-3 1,2-dibromo-11-chloro-undecane 

Downstream Products

• 91161-61-4 Heptadecanedioyl-Lys(Z)-OEt 
• 19102-92-2 dimethyl heptadecane-1,17-dioate 
• 72849-42-4 heptadecanedioic acid monomethyl ester 
• 94036-00-7 17-hydroxy-heptadecanoic acid methyl ester 
• 629-62-9 pentadecane 

Relevant academic research and scientific papers

Engineering of Orally Available, Ultralong-Acting Insulin Analogues: Discovery of OI338 and OI320

Recently, the first basal oral insulin (OI338) was shown to provide similar treatment outcomes to insulin glargine in a phase 2a clinical trial. Here, we report the engineering of a novel class of basal oral insulin analogues of which OI338, 10, in this publication, was successfully tested in the phase 2a clinical trial. We found that the introduction of two insulin substitutions, A14E and B25H, was needed to provide increased stability toward proteolysis. Ultralong pharmacokinetic profiles were obtained by attaching an albumin-binding side chain derived from octadecanedioic (C18) or icosanedioic acid (C20) to the lysine in position B29. Crucial for obtaining the ultralong PK profile was also a significant reduction of insulin receptor affinity. Oral bioavailability in dogs indicated that C18-based analogues were superior to C20-based analogues. These studies led to the identification of the two clinical candidates OI338 and OI320 (10 and 24, respectively).

Peptides for Treatment of Obesity

The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of obesity as well as a variety of diseases or conditions associated with obesity.

Biosynthesis of defensive coccinellidae alkaloids: Incorporation of fatty acids in adaline, coccinelline, and harmonine

In this study, we report on in vitro incorporation experiments of several labelled fatty acids in the ladybird alkaloids coccinelline (Coccinella 7-punctata), adaline (Adalia 2-punctata), and harmonine (Harmonia axyridis). The obtained results clearly indicate that stearic acid is the precursor of coccinelline and harmonine, whereas myristic acid is at the origin of the carbon skeleton of adaline. Possible pathways for the biosynthesis of these alkaloids are presented. In vitro incorporation experiments of labelled fatty acids in the ladybird alkaloids coccinelline (Coccinella 7-punctata), adaline (Adalia 2-punctata) and harmonine (Harmonia axyridis) indicate that stearicacid is the best precursor for the biosynthesis of coccinelline and harmonine, whereas myristic acid is more efficient for the formation of the carbon skeleton of adaline. Copyright

One-step Synthesis of Long-chain Aliphatic α,ω-Dicarboxylic Acids Utilizing the Copper-catalyzed Reaction of β-Propiolactone with α,ω-Di-Grignard Reagents

Copper-catalyzed reaction of β-propiolactone with α,ω-di-Grignard reagents, followed by esterification gave six-carbon homologated α,ω-dicarboxylic acid esters in good yields.