242475-00-9Relevant academic research and scientific papers
A facile one-pot regioselective synthesis of [1,2,4]triazolo[4,3-a]5(1H)-pyrimidinones via tandem Japp-Klingemann, smiles rearrangement, and cyclization reactions
Shawali, Ahmad S.,Abdallah, Magda A.,Mosselhi, Mosselhi A. N.,Farghaly, Thoraya A.
, p. 136 - 140 (2007/10/03)
Coupling of active [(4-oxo-6-phenyl-3H-pyrimidin-2-yl)thio]methine compounds (3) with diazotized anilines in the presence of base gave [1,2,4]triazolo[4,3-a]pyrimidines (7). The latter products were also obtained by reactions of hydrazonoyl chlorides (10)
Synthesis of pyrimidine, thiazolopyrimidine, pyrimidotriazine and triazolopyrimidine derivatives and their biological evaluation
Attaby, Fawzy A.,Eldin, Sanaa M.
, p. 788 - 798 (2007/10/03)
Pyrimidin-4-one-2-thione (3) was synthesized via the reaction of thiourea (1) with ethyl henzoylacetate (2) and was taken as a starting material for the present study via its reactions with the halogen-containing reagents 6a-d and 10a-c to give the corresponding thiazolopyrimidines 8, 9 and 12a-c. The 2-hydrazino derivatives 5 were synthesized either via the reaction of 3 or 4 with hydrazine hydrate. Compound 5 reacted with 6a-c and 10a-c to give the corresponding pyrimidotriazines 17a-c and 19 respectively. Also, compound 5 reacted with the active methylene-containing reagents 13 and 2a,b to give the corresponding 2-pyrazolopyrimidines 15 and 22a,b respectively. On the other hand, the triazolopyrimidines 21a,b and 30a,b were also obtained via the reaction of 5 with each of formic acid, acetic anhydride, ethyl chloroformate and carbon disulfide respectively. Some of the newly synthesized heterocyclic derivatives were tested for their biological activity.
