24248-21-3

Basic information

• Product Name: ETHYL 3-(2,6-DICHLORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLATE
• Synonyms: ETHYL 3-(2,6-DICHLORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLATE;Ethyl3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolecarboxalate;3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolecarboxylic acid ethyl ester;3-(2,6-dichlorophenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester;ethyl 3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazole-4-carboxylate;3-(2,6-Dichlorophenyl)-5-Methyl-4-isoxazolylcarboxylic Acid Ethyl Ester
• CAS NO: 24248-21-3
• Molecular Formula: C₁₃H₁₁Cl₂NO₃
• Molecular Weight: 300.14
• EINECS: 246-108-3
• Mol File: 24248-21-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 394.8°C at 760 mmHg
• Flash Point: 192.6°C
• Appearance: /
• Density: 1.332g/cm³
• Vapor Pressure: 1.93E-06mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: -20°C Freezer
• Solubility: Acetontrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: ETHYL 3-(2,6-DICHLORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 3-(2,6-DICHLORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLATE(24248-21-3)
• EPA Substance Registry System: ETHYL 3-(2,6-DICHLORO-PHENYL)-5-METHYL-ISOXAZOLE-4-CARBOXYLATE(24248-21-3)

Safety Data

• Hazardous Substances Data: 24248-21-3(Hazardous Substances Data)

Usage

Chemical Properties

Off-white Solid

Uses

3-(2,6-Dichlorophenyl)-5-Methyl-4-isoxazolylcarboxylic Acid Ethyl Ester is used in the preparation of novel isoxazole carboxamides as growth hormones.

InChI:InChI=1/C13H11Cl2NO3/c1-3-18-13(17)10-7(2)19-16-12(10)11-8(14)5-4-6-9(11)15/h4-6H,3H2,1-2H3

Upstream product

• 25185-95-9 2,6-dichlorobenzaldoxime 
• 6579-27-7 2,6-dichlorobenzohydroximoyl chloride 
• 105-45-3 acetoacetic acid methyl ester 
• 83-38-5 2,6-dichlorobenzaldehyde 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 1268246-42-9 C₁₄H₁₁Cl₂NO₄ 
• 1268246-43-0 C₁₄H₁₃Cl₂NO₄ 
• 1268246-44-1 C₁₉H₂₁Cl₂NO₅ 
• 1268246-45-2 C₁₇H₁₉Cl₂NO₄ 
• 4462-55-9 3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolylcarbonyl chloride 
• 1268246-41-8 (E)-ethyl 3-(2,6-dichlorophenyl)-5-(2-(dimethylamino)vinyl)isoxazole-4-carboxylate 
• 1610688-84-0 diethyl 5,5'-((1E,3Z)-4-(dimethylamino)buta-1,3-diene-1,3-diyl)bis(3-(2,6-dichlorophenyl)isoxazole-4-carboxylate) 
• 848186-99-2 3-(2,6-dichlorophenyl)-N-[4-(diethylamino)-2-methoxyphenyl]-5-methylisoxazole-4-carboxamide 

Relevant articles and documents

ISOXAZOLYL-CARBONYLOXY AZABICYCLO[3.2.1]OCTANYL COMPOUNDS AS FXR ACTIVATORS

The disclosure relates to activators of FXR useful in the treatment of autoimmune disorders, liver disease, intestinal disease, kidney disease, cancer, and other diseases in which FXR plays a role, having the Formula (I): wherein L1, L2, A, B, R1, R2, R3, and R4 are described herein.

The first low μM SecA inhibitors

SecA ATPase is a critical member of the Sec family, which is important in the translocation of membrane and secreted polypeptides/proteins in bacteria. Small molecule inhibitors can be very useful research tools as well as leads for future antimicrobial agent development. Based on previous virtual screening work, we optimized the structures of two hit compounds and obtained SecA ATPase inhibitors with IC50 in the single digit micromolar range. These represent the first low micromolar synthetic inhibitors of bacterial SecA and will be very useful for mechanistic studies.

Novel isoxazole carboxamides as growth hormone secretagogue receptor (GHS-R) antagonists

Novel isoxazole carboxamides have been identified as growth hormone secretagogue receptor (GHS-R) antagonists. Substituent modification off the 5-position of the isoxazole ring led to analogues with potent binding affinity and functional antagonism of GHS-R. A potent analogue (32) with high aqueous solubility and good GPCR selectivity was also identified as a potential pharmacological tool for in vivo studies.