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242801-86-1

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242801-86-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 242801-86-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,2,8,0 and 1 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 242801-86:
(8*2)+(7*4)+(6*2)+(5*8)+(4*0)+(3*1)+(2*8)+(1*6)=121
121 % 10 = 1
So 242801-86-1 is a valid CAS Registry Number.

242801-86-1Upstream product

242801-86-1Downstream Products

242801-86-1Relevant articles and documents

Design and synthesis of new donepezil analogs derived from arylpiperazine scaffold as acetylcholinesterase inhibitors

Sahin, Zafer,Biltekin, Sevde Nur,Bülbül, Emre Fatih,Yurttas, Leyla,Berk, Barkin,Demirayak, ?eref

, p. 283 - 293 (2020/10/29)

Newly synthesized 4-substituted phenyl-2-(4-substituted phenylpiperazine-1-yl)thiazole derivatives (4a–v) were evaluated in terms of their acetylcholinesterase (AChE) inhibition activities. Twenty-two compounds were tested against AChE at six different concentrations that varied between 10?4 and 10?9 M. The concentrations that inhibited AChE were calculated between 1.15 and 3.45 μM in seven compounds (4a, 4b, 4h, 4l, 4m, 4q, 4r). Compounds 4m, 4b, and 4l represented 1.15, 1.31, 1.34 μM (IC50) inhibitions, respectively. Although the inhibition values are lower than that of donepezil, they are considerable. Modeling studies of these analogs revealed similar positioning with donepezil, in which Ar–Ar interactions with Tyr337 and Trp 286 exist.

Substituted 1,3-thiazole compounds, their production and use

-

, (2008/06/13)

(1) A 1,3-thiazole compound of which the 5-position is substituted with a 4-pyridyl group having a substituent including no aromatic group or (2) a 1,3-thiazole compound of which the 5-position is substituted with a pyridyl group having at the position adjacent to a nitrogen atom of the pyridyl group a substituent including no aromatic group has an excellent p38 MAP kinase inhibitory activity.

p38MAP KINASE INHIBITORS

-

, (2008/06/13)

A 1,3-thiazole compound substituted at the 5-position by a pyridyl group optionally having substituent(s) has a superior p38 MAP kinase inhibitory activity and TNF-α production inhibitory activity.

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