24281-83-2Relevant academic research and scientific papers
Sialic acid derivatives
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, (2008/06/13)
Sialic acid derivatives represented by the general formula (I): STR1 wherein R1 is a steroidal compound residue; R2 is H or alkyl; R3 is alkyl; STR2 wherein each of R6 and R7 is H, alkyl or the like and I is an integer of 0 to 6; or the like; X is O or S; R4 is H or acyl; and R5 is R14 O-- (R14 is H or acyl) or R15 NH--(R15 is acyl or the like); their salts, hydrates or solvates are provided. Sialic acid derivatives of the present invention are expected to be effective medicines for the prevention and therapy of senile dementia including Alzheimer's disease and the like, because they increase ChAT activity in cholinergic neurons.
Sialic acid derivatives
-
, (2008/06/13)
Sialic acid derivatives represented by the general formula (I): wherein R1 is a steroidal compound residue; R2 is H or alkyl; R3 is alkyl; STR1 wherein each of R6 and R7 is H, alkyl or the like and I is an integer of 0 to 6; or the like; X is O or S; R4 is H or acyl; and R5 is R14 O--(R14 is H or acyl) or R15 NH--(R15 is acyl or the like); their salts, hydrates or solvates are provided. Sialic acid derivatives of the present invention are expected to be effective medicines for the prevention and therapy of senile dementia including Alzheimer's disease and the like, because they increase ChAT activity in cholinergic neurons.
