24289-99-4Relevant articles and documents
Synthesis of neolignans as microtubule stabilisers
Sathish Kumar,Singh, Aastha,Kumar, Amit,Singh, Jyotsna,Hasanain, Mohammad,Singh, Arjun,Masood, Nusrat,Yadav, Dharmendra K.,Konwar, Rituraj,Mitra, Kalyan,Sarkar, Jayanta,Luqman, Suaib,Pal, Anirban,Khan, Feroz,Chanda, Debabrata,Negi, Arvind S.
, p. 1342 - 1354 (2014/03/21)
Tubulin is a well established target for anticancer drug development. Lignans and neolignans were synthesized as tubulin interacting agents. Neolignans 10 and 19 exhibited significant anticancer activity against MCF-7 and MDAMB-231 human breast cancer cell lines. Both the compounds effectively induced stabilization of microtubule at 4 and 20 μM concentrations respectively. Neolignan 10 induced G2/M phase arrest in MCF-7 cells. Docking experiments raveled that 10 and 19 occupied the same binding pocket of paclitaxel with some difference in active site amino acids and good bioavailability of both the compounds. In in vivo acute oral toxicity 10 was well tolerated up to 300 mg/kg dose in Swiss-albino mice.
Synthesis of 3,4-Bis-dihydro-2(3H)-furanones and 2,3-Bis(m- or p-substituted-benzyl)-butane-1,4-diols.
Neelima,Bhaduri, A. P.
, p. 209 - 215 (2007/10/02)
Stobbe condensation of appropriately substituted aromatic aldehydes with diethyl or dimethyl succinate in the presence of sodium methoxide yields the required starting materials for the synthesis of the title compounds.The diacids (1-4) and half acid-half
