24301-72-2Relevant academic research and scientific papers
A dual-site two-photon fluorescent probe for visualizing mitochondrial aminothiols in living cells and mouse liver tissues
Meng, Fangfang,Liu, Yong,Yu, Xiaoqiang,Lin, Weiying
, p. 7399 - 7406 (2016)
Thiol-containing amino acids (RSH) play a key role in maintaining the redox environment. In this work, we developed a novel dual-site two-photon (TP) fluorescent RSH probe (CA-TPP) for imaging mitochondrial RSH in living cells and mouse liver tissues. This probe exhibited rapid response and high TP photostability towards mitochondrial RSH. In particular, probe CA-TPP was capable of using TP fluorescence to track mitochondrial RSH over a long period.
Stilbene like carbazole dimer-based electroluminescent materials
Chen, Chih-Hsin,Lin, Jiann T.,Yeh, Ming-Chang P.
, p. 8564 - 8570 (2006)
Two carbazole dimers (1 and 10) were synthesized from 9-ethyl-9H-carbazole-3-carbaldehyde and 6-bromo-9-ethyl-9H-carbazole-3-carbaldehyde by McMurry C-C coupling reaction. Palladium(0)-catalyzed C-N coupling reactions of 10 and various diarylamines result in the formation of stable carbazole derivatives in good yields. These compounds are fluorescent in blue to yellow region with moderate to good quantum yields. Also, they are thermally stable and capable of hole-transporting due to the presence of the carbazole moieties. The electroluminescent devices fabricated using 1, 2, and 3 as hole-transporters/emitters with a bilayer structure ITO/Cpd/TPBI or Alq3/LiF/Al (Cpd=1, 2, and 3) exhibit good performance (e.g., ηext=1.0-2.1%; ηp=0.9-1.9 lm/W; ηc=2.4-4.8 cd/A at a current density of 100 mA/cm2).
Synthesis, photophysical and electrochemical properties of a carbazole dimer-based derivative with benzothiazole units
Shi, He-Ping,Dai, Jian-Xin,Shi, Li-Wen,Xu, Lei,Zhou, Zhao-Bin,Zhang, Yan,Zhou, Wen,Dong, Chuan
, p. 19 - 25 (2012)
A novel A-π-D-π-D-π-A type compound, containing two benzothiazole rings as electron acceptors and two N-ethylcarbazole groups as electron donors, (E)-1,2-bis(3-(benzothiazol-2-yl)-9-ethylcarbazol-6-yl)ethene (BBECE), was synthesized and characterized by elemental analysis, NMR, MS and thermogravimetric analysis. Electrochemical property of compound BBECE was studied by cyclic voltammetry analysis. The absorption and emission spectra of BBECE was experimentally determined in several solvents and simultaneously computed using density functional theory (DFT) and time-dependent density functional theory (TDDFT). The calculated absorption and emission wavelengths are coincident with the measured data. The lowest-lying absorption spectra can be mainly attributed to intramolecular charge transfer (ICT), and the fluorescence spectra can be mainly described as originating from an excited state with intramolecular charge transfer (ICT) character. The molecular orbitals (HOMO and LUMO), the ionization potential (IP), the electron affinity (EA) and reorganization energy of compound BBECE were also investigated using density functional theory (DFT). The results show that compound BBECE exhibited excellent thermal stability and electrochemical stability as well as high fluorescence quantum yield, indicating its potential applications as an excellent optoelectronic material in optical fields.
Facilitated interfacial charge separation using triphenylamine-zinc porphyrin dyad-sensitized TiO2 nanoparticles for photocatalysis
Chen, Yan,Mo, Zhao,Zhu, Xingtong,Xu, Qingxiang,Xue, Zhaoli,Li, Henan,Xu, Hui,Zhao, Long
supporting information, (2021/09/06)
Three triphenylamine (TPA) substituted dichromophoric zinc porphyrins XZP1–3 and a single zinc porphyrin ZP1 have been rationally designed to construct dye-sensitized TiO2 nanoparticles to explore the feasibility of dichromophoric dye design for photocatalysis. TPA, N,N-diphenyl-(1,1′-biphenyl)? 4-amine and a carbazole-diphenylaniline derivative are attached to the meso-position of porphyrin core as the second chromophore. The electronic structure of the porphyrins is studied by density functional theory (DFT) calculations and the dye-sensitized composites are investigated using couples of spectral and electrochemical techniques. XZP2/TiO2 exhibits the smallest charge transfer resistance and the longest electron lifetime among the investigated composites. The same catalyst performs the highest efficiency in photodegradation of both acid black (AB1) and tetracycline (TC) polluted water samples. Electronic paramagnetic resonance and radical quenching experiments reveal that the priority reactive species are superoxide radicals (?O2?) and holes (h+), suggesting the efficient charge separation at the porphyrin-sensitized TiO2 interface. This work demonstrates the facilitated interfacial charge separation using dichromophoric dye-sensitized semiconductor particles for photodegradation and, the insights should aid in dyad design for photocatalysis application.
SMALL MOLECULE INHIBITORS OF SCL15A4 WITH ANTI-INFLAMMATORY ACTIVITY
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Page/Page column 30, (2021/09/04)
Disclosed are small molecule inhibitors of SLC15A4, and methods of using them to treat pDC-mediated diseases and conditions.
Identification of a Benzimidazolecarboxylic Acid Derivative (BAY 1316957) as a Potent and Selective Human Prostaglandin E2 Receptor Subtype 4 (hEP4-R) Antagonist for the Treatment of Endometriosis
B?urle, Stefan,Nagel, Jens,Peters, Olaf,Br?uer, Nico,Ter Laak, Antonius,Preusse, Cornelia,Rottmann, Antje,Heldmann, Dieter,Bothe, Ulrich,Blume, Thorsten,Zorn, Ludwig,Walter, Daryl,Zollner, Thomas M.,Steinmeyer, Andreas,Langer, Gernot
, p. 2541 - 2563 (2019/04/03)
The presence and growth of endometrial tissue outside the uterine cavity in endometriosis patients are primarily driven by hormone-dependent and inflammatory processes - the latter being frequently associated with severe, acute, and chronic pelvic pain. T
p-TsOH-mediated, Versatile, and Efficient Approach for the Synthesis of Triazolyl-Carbazoles from Nitrovinylcarbazoles and Azide via 1, 3-Dipolar Cycloaddition
Avula, Vijay Kumar Reddy,Vallela, Swetha,Anireddy, Jaya Shree,Chamarthi, Naga Raju
, p. 1361 - 1368 (2017/03/27)
An efficient method for the synthesis of N-alkylated 3-(1-benzyl-1H-1,2,3-triazole-4-yl)-9H-carbazoles (5, 6, 7, 8, 9, 10) and 9-ethyl-3,6-di(1H-1,2,3-triazole-4-yl)-9H-carbazole (13) has been developed from nitroolefines. The effects of catalyst and solvent on these reactions have been investigated. p-TsOH-THF was found to be the best system for this reaction. Various triazolyl-carbazoles were prepared in good to excellent yields.
A boron-containing carbazole dimer: Synthesis, photophysical properties and sensing properties
Shi, He-Ping,Dai, Jian-Xin,Xu, Lei,Shi, Li-Wen,Fang, Li,Shuang, Shao-Min,Dong, Chuan
experimental part, p. 3852 - 3858 (2012/06/04)
A novel boron-containing π-conjugated compound BCCB has been synthesized by the introduction of electron-acceptors (dimesitylboron groups) at the 3,3′-positions of a carbazole dimer (electron-donor). The compound BCCB possesses excellent electrochemical properties and high fluorescence quantum yields. In addition, BCCB is a sensitive fluorescence sensor with remarkable colour changes and the results could be confirmed through theoretical calculations of the compounds BCCB and [nBu4N] +2[BCCB·(F)2]2-. Our studies indicate that BCCB could be used as an excellent optoelectronic material in OLED devices and a ratiometric fluorescent chemosensor.
Highly selective red- and green-emitting two-photon fluorescent probes for cysteine detection and their bio-imaging in living cells
Yang, Zhiguang,Zhao, Ning,Sun, Yuming,Miao, Fang,Liu, Yong,Liu, Xin,Zhang, Yuanhong,Ai, Wentao,Song, Guofen,Shen, Xiaoyuan,Yu, Xiaoqiang,Sun, Jingzhi,Wong, Wai-Yeung
supporting information; experimental part, p. 3442 - 3444 (2012/05/20)
Two highly selective two-photon fluorescent probes for cysteine over homocysteine, N-acetyl-l-cysteine, dithiothreitol, glutathione and other amino acids, and their fluorescent imaging in living cells have been shown.
A facile method for the synthesis of acetylcarbazoles and carbazole aldehydes
Nagarajan, Rajagopal,Perumal, Paramasivan T.
, p. 2127 - 2133 (2007/10/03)
Acetylation of 9-alkylcarbazoles with acetic anhydride catalyzed by PPh3. HClO4 was reported to give acetylcarbazoles. Carbazole aldehydes were easily synthesized by the Vilsmeier reaction of 9-alkylcarbazoles under microwave condition in good yields.
