24302-04-3Relevant academic research and scientific papers
A general synthetic method for the formation of substituted 5-aminotetrazoles from thioureas: a strategy for diversity amplification.
Batey,Powell
, p. 3237 - 3240 (2000)
A general method for the synthesis of 5-aminotetrazoles is outlined using the mercury(II)-promoted attack of azide anion on a thiourea. The reaction proceeds through a guanyl azide intermediate, which undergoes electrocyclization to the tetrazole. The method is high yielding and provides access to mono-, di-, and trisubstituted 5-aminotetrazoles, targets of potential interest for combinatorial library development.
