2742-67-8

Basic information

• Product Name: Thiourea, N,N-diethyl-N'-(phenylmethyl)-
• CAS NO: 2742-67-8
• Molecular Formula: C12H18N2S
• Molecular Weight: 222.354
• Mol File: 2742-67-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Thiourea, N,N-diethyl-N'-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiourea, N,N-diethyl-N'-(phenylmethyl)-(2742-67-8)
• EPA Substance Registry System: Thiourea, N,N-diethyl-N'-(phenylmethyl)-(2742-67-8)

Safety Data

• Hazardous Substances Data: 2742-67-8(Hazardous Substances Data)

Upstream product

• 622-78-6 Benzyl isothiocyanate 
• 109-89-7 diethylamine 
• 75-15-0 carbon disulfide 
• 100-46-9 benzylamine 
• 71055-98-6 (Bromo-isothiocyanato-methyl)-benzene 
• 88333-03-3 Benzyl isocyanide 
• 97-77-8 disulfiram 
• 88-11-9 N,N-diethylthiocarbamoyl chloride 
• 71055-99-7 1,1-Diethyl-3-[1-phenyl-meth-(E)-ylidene]-thiourea 

Downstream Products

• 39531-32-3 3-benzyl-1,1-diethylurea 
• 24302-04-3 (1-benzyl-1H-tetrazol-5-yl)-diethyl-amine 

Relevant articles and documents

A dithioxo-bishydroxylaminomolybdenum complex as sulfur and nitrogen transfer reagent. Synthesis of thioureas from isonitriles

Cis-dithioxo-bis(N,N-diethyl)hydroxylamido(I-)-O,N)molybdenum(VI) reacts with isonitriles to give the corresponding N,N-diethylthioureas. A mechanism is proposed for this S,N-transfer reaction.

Antileishmanial thioureas: Synthesis, biological activity and in Silico evaluations of new promising derivatives

Leishmaniasis is a neglected tropical disease caused by protozoan parasites belonging to the genus Leishmania. Currently, the drugs available for treatment of this disease present high toxicity, along with development of parasite resistance. In order to overcome these problems, efforts have been made to search for new and more effective leishmanicidal drugs. The aim of this study was to synthesize and investigate the leishmanicidal effect of N,N′-disubstituted thioureas against Leishmania amazonensis, with evaluation of their in silico pharmacokinetics and toxicity profiles. Our results showed that different thioureas could be obtained in high to moderate yields using simple reaction conditions. Nine thiourea derivatives (3e, 3i, 3k, 3l, 3p, 3q, 3v, 3x and 3z) were active against parasite promastigotes (IC50 21.48–189.10μM), with low cytotoxicity on mice peritoneal macrophages (CC50>200μM), except for thiourea 3e (CC50=49.22μM). After that, the most promising thioureas (3k, 3l, 3p, 3q and 3v) showed IC50 ranging from 70 to 150μM against L. amazonensis amastigotes in infected macrophages. Except for thiourea 3p, the leishmanicidal activity of the derivatives were independent of nitric oxide (NO) production. Thioureas 3q and 3v affected promastigotes cell cycle without disturbing the mitochondrial membrane potential. Furthermore, our derivatives showed satisfactory theoretical absorption, distribution, metabolism, excretion, toxicity (ADMET) properties. These data indicate that thiourea derivatives are good candidates as leading compounds for the development of new leishmanicidal drugs.

A highly efficient one-pot method for the synthesis of thioureas and 2-imino-4-thiazolidinones under microwave conditions

A one-pot synthesis of symmetrical and unsymmetrical substituted thioureas and 2-imino-4-thiazolidinones from simple starting materials under microwave irradiation and solventless conditions without base additives is presented. Various di- and trisubstituted thioureas are obtained in good yields in a few minutes. The sequential, three-component, one-pot synthesis of 2-imino-4-thiazolidinone derivatives is also studied, with satisfactory results obtained.