24305-63-3 Usage
Description
Glycidyl Linoleate, also known as GL, is a naturally occurring fatty acid ester derived from the reaction of the unsaturated fatty acid linoleic acid with epichlorohydrin. It is a colorless to pale yellow solid with unique chemical properties that make it a versatile compound in various industries.
Uses
Used in Pharmaceutical Industry:
Glycidyl Linoleate is used as a potential inhibitor for Monoacylglycerol Lipase (MAGL), an enzyme involved in the degradation of endocannabinoids. By inhibiting this enzyme, GL can modulate the endocannabinoid system, which has implications for various therapeutic applications, including pain management and neuroprotection.
Used in Chemical Industry:
Due to its unique chemical properties, Glycidyl Linoleate can be used as a starting material for the synthesis of various derivatives, such as epoxy resins, surfactants, and other specialty chemicals. Its versatility as a building block makes it valuable in the development of new materials and products.
Used in Cosmetics Industry:
Glycidyl Linoleate's compatibility with skin and its ability to form stable emulsions make it a suitable ingredient for cosmetics and personal care products. It can be used as an emollient, moisturizer, or viscosity modifier, enhancing the texture and feel of creams, lotions, and other formulations.
Used in Food Industry:
As a derivative of linoleic acid, Glycidyl Linoleate can be utilized in the food industry for various applications, such as a stabilizer, emulsifier, or texturizer. Its ability to improve the properties of food products without affecting their taste or appearance makes it a valuable additive in the industry.
Check Digit Verification of cas no
The CAS Registry Mumber 24305-63-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,3,0 and 5 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 24305-63:
(7*2)+(6*4)+(5*3)+(4*0)+(3*5)+(2*6)+(1*3)=83
83 % 10 = 3
So 24305-63-3 is a valid CAS Registry Number.
24305-63-3Relevant articles and documents
Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis - Comparison with effects upon fatty acid amide hydrolase
Cisneros, José Antonio,Vandevoorde, Séverine,Ortega-Gutiérrez, Silvia,Paris, Clément,Fowler, Christopher J.,López-Rodríguez, María L.
, p. 5012 - 5023 (2008/03/12)
A series of 32 heterocyclic analogues based on the structure of 2-arachidonoylglycerol (2-AG) were synthesized and tested for their ability to inhibit monoacylglycerol lipase and fatty acid amide hydrolase activities. The designed compounds feature a hydrophobic moiety and different heterocyclic subunits that mimic the glycerol fragment. This series has allowed us to carry out the first systematic structure-activity relationship study on inhibition of 2-AG hydrolysis. The most promising compounds were oxiran-2-ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate (1) and tetrahydro-2H-pyran-2- ylmethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate (5). They inhibited cytosolic 2-oleoylglycerol (2-OG) hydrolysis completely (IC50 values of 4.5 and 5.6 μM, respectively). They also blocked, albeit less potently, 2-OG hydrolysis in membrane fractions (IC50 values of 19 and 26 μM, respectively) and anandamide hydrolysis (IC50 values of 12 and 51 μM, respectively). These compounds will be useful in delineating the importance of the cytosolic hydrolytic activity in the regulation of 2-AG levels and, hence, its potential as a target for drug development.
