24313-49-3Relevant academic research and scientific papers
Microwave-assisted deuterium exchange reactions for the preparation of reactive intermediates
Fodor-Csorba, Katalin,Galli, Giancarlo,Holly, Sándor,Gács-Baitz, Eszter
, p. 3789 - 3792 (2002)
Deuterium labelling of a number of ketones was achieved on a preparative scale by a microwave-assisted deuterium exchange reaction with D2O/CF3COOD. The reaction was rapid (15 min) and highly isotope-efficient (ca. 100%), even though deuterium incorporation can be decreased during work-up (85-90%). No exchange reaction was observed for aryl protons of aromatic ketones.
Aerobic oxidation of alkenes mediated by porphyrin rhodium(iii) complexes in water
Zhang, Jiadi,Li, Shan,Fu, Xuefeng,Wayland, Bradford B.
scheme or table, p. 3661 - 3663 (2009/08/15)
Selective oxidation of alkenes in water to ketones using molecular oxygen as the oxidant is mediated by rhodium porphyrin complexes through observed β-hydroxy alkyl complexes.
HIGHLY SELECTIVE and LONG-ACTING PDE5 MODULATORS
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Page/Page column 62, (2008/12/07)
Disclosed herein are substituted phosphodiesterase type 5 enzyme modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
Thermal decomposition of acetyl propionyl peroxide in acetone-d6
Skakovskii,Stankevich,Tychinskaya,Shirokii,Choban,Murashko,Rykov
, p. 1719 - 1725 (2007/10/03)
The kinetics of thermolysis of acetyl propinyl peroxide in acetone-d 6 in the temperature range 323-373 K was studied using NMR spectroscopy and the effect of chemically induced nuclear polarization. The peroxide decomposes in acetone at rates comparable with the rates of thermolysis in alcohols, yielding numerous products. In the examined temperature range, the solvent molecules act as efficient donors of deuterium atoms, forming acetylmethyl-d5 radicals which recombine to a significant extent with the peroxide radicals. A scheme of the processes involved in decomposition of the peroxide was suggested. The parameters of the Arrhenius equation for the peroxide decomposition were determined. 2004 MAIK "Nauka/ Interperiodica".
CH-π interaction as an important driving force of host-guest complexation in apolar organic media. Binding of monools and acetylated compounds to resorcinol cyclic tetramer as studied by 1H NMR and circular dichroism spectroscopy
Kobayashi, Kenji,Asakawa, Yuji,Kikuchi, Yasuaki,Toi, Hiroo,Aoyama, Yasuhiro
, p. 2648 - 2653 (2007/10/02)
The CH-π interaction plays an important role in the complexation involving resorcinol cyclic tetramer 1 in chloroform. Thus, host 1 binds simple monools 4-10 via a cooperation of CH-π and hydrogen-bonding interactions, where the binding constants at 298 K (up to 13 M-1) increase with increasing chain lengths (from ethyl through propyl to butyl) as well as branching in the aliphatic moiety of the guests. In addition, the largest complexation-induced 1H NMR upfield shift for a bound guest occurs at the terminal methyl group, which must therefore be deeply incorporated in the aromatic cavity of the host. The complexes derived from chiral secondary alcohols 10-17 including terpenes and steroids exhibit induced circular dichroism as a result of guest-to-host chirality transfer which is mediated by the CH-π interaction. Borneol (14) having three methyl groups to allow a multipoint CH-π interaction forms a particularly stable complex (K = 54 M-1). The acetyl group in a guest is significantly complexation-promoting. This is primarily due to enhanced CH-π interaction involving the polarized C-H bonds of the acetyl group. The binding constants for selected guests are K = 35, 12, 4, and 1 M-1 for 3-oxo-1-butanol (simple alcohol having an acetyl group), bornyl acetate (monoacetate having a bulky and highly branched aliphatic moiety), 2,4-diacetoxypentane (simple diacetate), and cholestane (bulky hydrocarbon), respectively.
Characterizaton of Five + Ion Structures. Fragmentation of the 2-Pentanone Molecular Ion
Laderoute, Keith R.,Zwinselman, Jan J.,Harrison, Alex. G.
, p. 25 - 33 (2007/10/02)
The + ions + (1), + (2), + (3), O>+ (4), and O>+ (5) have been characterized by their collision-induced dissociation (CID) mass spectra and charge stripping mass spectra.The ions 1-3 were prepared by gas phase protonation of the relevant carbonyl compounds while 4 and 5 were prepared by dissociative electron impact ionization of the appropriate carbonyl compounds.Only 2 and 3 give similar spectra and are difficult to distinguish from each other; the remaining ions can be readily characterized by either their CID mass spectra or their charge stripping mass spectra.The 2-pentanone molecular ion fragments by loss of the C(1) methyl and the C(5) methyl in the ratio 60:40 for metastable ions: at higher internal energies loss of the C(1) methyl becomes more favoured.Metastable ion characteristics, CID mass spectra and charge stripping mass spectra all show that loss of the C(1) methyl leads to formation of the acyl ion 4, while loss of the C(5) methyl leads to formation of protonated vinyl methyl ketone (1).These results are in agreement with the previously propossed potential energy diagram for the +. system.
