243136-08-5Relevant articles and documents
Pilot-plant preparation of an αβ3 integrin antagonist: Process development of a carbonyldiimidazole peptide coupling
Weisenburger, Gerald A.,Anderson, D. Keith,Clark, Jerry D.,Edney, Albert D.,Karbin, Punch S.,Gallagher, Donald J.,Knable, Carl M.,Pietz, Mark A.
experimental part, p. 60 - 63 (2010/04/22)
The process development of a peptide coupling with CDI is discussed. Various solvents, addition orders, stoichiometries, and reaction temperatures were investigated. A reliable crystallization procedure was also developed. The new process was piloted to p